:root {
  color-scheme: dark;
  --black: #07100e;
  --field-deep: #07100e;
  --field: #0a1411;
  --surface: #0f1b17;
  --surface-raised: #14231d;
  --surface-soft: #192a23;
  --overlay: rgba(15, 28, 23, .88);
  --ink: #edf4ef;
  --ink-soft: #cbd8cf;
  --muted: #9cada2;
  --dim: #718078;
  --line: rgba(224, 239, 229, .11);
  --line-strong: rgba(224, 239, 229, .22);
  --brand: #ef4863;
  --brand-bright: #ff6b82;
  --cyan: #6bc5d2;
  --amber: #e4b866;
  --violet: #aa99da;
  --bio: #70d6aa;
  --danger: #ef6b78;
  --paper: #f0ecdf;
  --paper-raised: #f7f3e8;
  --paper-line: #d7cfbd;
  --paper-ink: #17201d;
  --max: 1440px;
  --text: 760px;
  --mono: ui-monospace, SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", monospace;
  --sans: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
}

* { box-sizing: border-box; }
html { min-width: 0; scroll-behavior: smooth; }
body {
  min-width: 0;
  margin: 0;
  background: var(--field-deep);
  color: var(--ink);
  font: 400 16px/1.65 var(--sans);
  text-rendering: optimizeLegibility;
}
body::before {
  position: fixed;
  inset: 0;
  z-index: -2;
  content: "";
  pointer-events: none;
  background:
    radial-gradient(950px 560px at 76% -180px, rgba(239, 72, 99, .105), transparent 67%),
    radial-gradient(720px 560px at 2% 38%, rgba(112, 214, 170, .075), transparent 72%),
    radial-gradient(640px 520px at 94% 72%, rgba(107, 197, 210, .045), transparent 70%),
    var(--field-deep);
}
body::after {
  position: fixed;
  inset: 0;
  z-index: -1;
  content: "";
  pointer-events: none;
  opacity: .24;
  background-image: linear-gradient(rgba(150, 195, 172, .028) 1px, transparent 1px), linear-gradient(90deg, rgba(150, 195, 172, .028) 1px, transparent 1px);
  background-size: 88px 88px;
  mask-image: linear-gradient(to bottom, #000, transparent 78%);
}
main, section, article, aside, form, div, nav { min-width: 0; }
img, svg, video, canvas { display: block; max-width: 100%; }
button, input, select, textarea { max-width: 100%; font: inherit; }
button, select { cursor: pointer; }
a { color: inherit; text-underline-offset: 4px; text-decoration-color: rgba(255, 23, 69, .65); }
a:hover { color: var(--brand-bright); }
code { font: .88em/1.45 var(--mono); overflow-wrap: anywhere; }
::selection { color: #fff; background: rgba(255, 23, 69, .42); }
:focus-visible { outline: 3px solid var(--brand-bright); outline-offset: 4px; border-radius: 2px; }
.visually-hidden { position: absolute !important; width: 1px; height: 1px; padding: 0; margin: -1px; overflow: hidden; white-space: nowrap; clip: rect(0, 0, 0, 0); border: 0; }
.skip-link { position: fixed; left: 1rem; top: -8rem; z-index: 100; padding: .7rem 1rem; border: 1px solid var(--brand); background: #050507; font: 700 .8rem var(--mono); text-decoration: none; }
.skip-link:focus { top: 1rem; }

.site-head { position: sticky; top: 0; z-index: 50; border-bottom: 1px solid var(--line); background: rgba(7, 16, 14, .88); backdrop-filter: blur(20px) saturate(1.12); box-shadow: 0 12px 36px rgba(0, 0, 0, .18); }
.head-inner { display: grid; grid-template-columns: auto 1fr minmax(220px, 300px); align-items: center; width: min(100%, var(--max)); min-height: 74px; margin: auto; padding: 0 clamp(1rem, 3vw, 2.75rem); gap: clamp(1rem, 3vw, 3rem); }
.brand { display: flex; align-items: center; gap: .7rem; text-decoration: none; }
.brand-mark { display: grid; place-items: center; width: 38px; height: 38px; border: 1px solid rgba(255, 23, 69, .38); background: rgba(255, 23, 69, .045); box-shadow: 0 0 24px rgba(255, 23, 69, .08); }
.brand-mark img { width: 34px; height: 34px; }
.brand-copy { display: grid; line-height: 1.1; }
.brand-copy strong { font-size: 1rem; letter-spacing: -.02em; }
.brand-copy span { margin-top: .2rem; color: var(--muted); font: 600 .58rem var(--mono); letter-spacing: .08em; text-transform: uppercase; }
.desktop-nav { display: flex; min-width: 0; align-items: center; justify-content: center; gap: clamp(.8rem, 1.5vw, 1.45rem); }
.desktop-nav-group { display: grid; gap: .2rem; }
.desktop-nav-group > span { color: var(--dim); font: 650 .52rem/1 var(--mono); letter-spacing: .12em; text-transform: uppercase; }
.desktop-nav-group > div { display: flex; gap: clamp(.5rem, .8vw, .85rem); }
.desktop-nav a { position: relative; padding: .25rem 0 .35rem; color: var(--ink-soft); font: 650 .68rem var(--mono); text-decoration: none; letter-spacing: .015em; white-space: nowrap; }
.desktop-nav a::after { position: absolute; left: 0; right: 0; bottom: -1px; height: 1px; content: ""; transform: scaleX(0); background: var(--brand); transition: transform .18s ease; }
.desktop-nav a:hover::after, .desktop-nav a[aria-current="page"]::after { transform: scaleX(1); }
.desktop-nav a[aria-current="page"] { color: var(--ink); }
.head-search { display: flex; min-height: 42px; overflow: hidden; border: 1px solid var(--line); border-radius: 10px; background: rgba(255, 255, 255, .025); }
.head-search:focus-within { border-color: rgba(255, 23, 69, .65); }
.head-search input { width: 100%; min-width: 0; padding: .5rem .65rem; border: 0; outline: 0; background: transparent; color: var(--ink); font: .72rem var(--mono); }
.head-search button { padding: .5rem .65rem; border: 0; border-left: 1px solid var(--line); background: transparent; color: var(--muted); font: 650 .62rem var(--mono); text-transform: uppercase; }
.mobile-nav { display: none; position: relative; }
.mobile-nav nav section { min-width: 0; }
.mobile-nav nav section + section { padding-top: .7rem; margin-top: .45rem; border-top: 1px solid var(--line); }
.mobile-nav nav h2 { margin: 0; padding: .35rem .65rem; color: var(--brand-bright); font: 700 .58rem/1.2 var(--mono); letter-spacing: .1em; text-transform: uppercase; }

.eyebrow { display: block; color: var(--brand-bright); font: 700 .66rem/1.4 var(--mono); letter-spacing: .13em; text-transform: uppercase; }
.button { display: inline-flex; min-height: 44px; align-items: center; justify-content: center; padding: .68rem 1rem; border: 1px solid var(--line-strong); border-radius: 10px; background: rgba(255, 255, 255, .025); color: var(--ink); font: 700 .72rem var(--mono); letter-spacing: .025em; text-decoration: none; text-transform: uppercase; }
.button:hover { border-color: rgba(239, 72, 99, .68); background: rgba(239, 72, 99, .09); color: var(--ink); }
.button.primary { border-color: rgba(239, 72, 99, .76); background: var(--brand); box-shadow: 0 12px 30px rgba(40, 4, 13, .22), inset 0 1px rgba(255,255,255,.14); }
.button.primary:hover { background: var(--brand-bright); }
.text-link, .back-link { color: var(--brand-bright); font: 700 .76rem var(--mono); }
.fine { color: var(--dim); font-size: .77rem; }

.hero { display: grid; grid-template-columns: minmax(0, 1.25fr) minmax(340px, .75fr); min-height: calc(100svh - 74px); align-items: center; gap: clamp(3rem, 8vw, 8rem); width: min(100%, var(--max)); padding: clamp(5rem, 10vw, 10rem) clamp(1.25rem, 6vw, 6rem); margin: auto; }
.hero-copy h1, .page-hero h1, .record-hero h1, .error-page h1 { max-width: 980px; margin: 1.1rem 0 1.4rem; font-size: clamp(3.4rem, 8.5vw, 8.5rem); font-weight: 280; line-height: .89; letter-spacing: -.075em; }
.hero-copy h1 em { color: var(--bio); font-style: normal; text-shadow: 0 0 32px rgba(115, 230, 174, .14); }
.lede { max-width: 770px; margin: 0; color: #c7cad0; font-size: clamp(1.05rem, 1.7vw, 1.35rem); line-height: 1.55; }
.hero-actions { display: flex; flex-wrap: wrap; gap: .7rem; margin-top: 2rem; }
.signal-row { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); margin: 3.5rem 0 0; border-top: 1px solid var(--line); border-bottom: 1px solid var(--line); }
.signal-row div { padding: 1.1rem .85rem; border-right: 1px solid var(--line); }
.signal-row div:first-child { padding-left: 0; }
.signal-row div:last-child { border: 0; }
.signal-row dt { color: var(--dim); font: 650 .6rem var(--mono); text-transform: uppercase; letter-spacing: .08em; }
.signal-row dd { margin: .25rem 0 0; color: var(--bio); font: 700 .76rem var(--mono); }
.hero-instrument { position: relative; padding: 1.4rem; border: 1px solid var(--line); background: linear-gradient(145deg, rgba(255, 23, 69, .05), rgba(115, 230, 174, .025) 58%, #050507); box-shadow: 0 26px 100px rgba(0, 0, 0, .5); }
.hero-instrument::before, .hero-instrument::after { position: absolute; width: 13px; height: 13px; content: ""; border-color: var(--brand); }
.hero-instrument::before { left: -1px; top: -1px; border-left: 1px solid; border-top: 1px solid; }
.hero-instrument::after { right: -1px; bottom: -1px; border-right: 1px solid; border-bottom: 1px solid; }
.instrument-label { display: block; color: var(--muted); font: 650 .61rem var(--mono); letter-spacing: .1em; text-transform: uppercase; }
.instrument-core { position: relative; display: grid; place-items: center; width: min(270px, 78%); aspect-ratio: 1; margin: 2.5rem auto; border: 1px solid rgba(115, 230, 174, .28); border-radius: 50%; }
.instrument-core::before, .instrument-core::after { position: absolute; inset: 16%; content: ""; border: 1px solid rgba(255, 23, 69, .28); transform: rotate(45deg); }
.instrument-core::after { inset: 33%; border-color: rgba(85, 216, 255, .35); transform: rotate(0); }
.instrument-core span { position: absolute; width: 8px; height: 8px; border: 1px solid var(--bio); border-radius: 50%; background: #000; box-shadow: 0 0 14px rgba(115, 230, 174, .5); }
.instrument-core span:nth-child(1) { left: -4px; top: 50%; }.instrument-core span:nth-child(2) { right: -4px; top: 50%; }.instrument-core span:nth-child(3) { left: 50%; top: -4px; }.instrument-core span:nth-child(4) { left: 50%; bottom: -4px; }
.instrument-core b { color: var(--brand); font: 700 1.2rem var(--mono); letter-spacing: .18em; }
.hero-instrument ol { display: grid; gap: 0; padding: 0; margin: 0; list-style: none; border-top: 1px solid var(--line); }
.hero-instrument li { display: grid; grid-template-columns: 6.5rem 1fr; gap: 1rem; padding: .72rem 0; border-bottom: 1px solid var(--line); font: .68rem var(--mono); }
.hero-instrument li strong { color: var(--brand-bright); }.hero-instrument li span { color: var(--muted); }

.feature-section, .content-shell, .index-shell, .source-shell, .download-shell, .comparison-shell, .search-results, .legal, .timeline { width: min(100%, var(--max)); padding: clamp(4.5rem, 9vw, 8rem) clamp(1.25rem, 5vw, 5rem); margin: auto; }
.feature-section { border-top: 1px solid var(--line); }
.section-heading { max-width: 850px; margin-bottom: 2.4rem; }
.section-heading h2, .release-boundary h2, .page-hero h1, .record-main h2, .comparison-shell h2, .method-prose h2 { margin: .75rem 0 1rem; font-size: clamp(2.15rem, 4.8vw, 4.7rem); font-weight: 320; line-height: 1.02; letter-spacing: -.055em; }
.section-heading p { max-width: 720px; color: var(--muted); }
.split-heading { display: grid; grid-template-columns: minmax(0, 1.1fr) minmax(280px, .55fr); max-width: none; gap: 3rem; align-items: end; }
.split-heading p { margin: 0; padding-left: 1.2rem; border-left: 1px solid var(--brand); }
.three-grid { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 1px; background: var(--line); border: 1px solid var(--line); }
.feature-card { display: flex; min-height: 330px; flex-direction: column; padding: clamp(1.5rem, 3vw, 2.4rem); background: linear-gradient(150deg, rgba(255,255,255,.018), transparent 42%), var(--surface); }
.feature-card:hover { background: linear-gradient(140deg, rgba(255, 23, 69, .055), var(--surface) 48%); }
.card-index { color: var(--brand); font: 700 .7rem var(--mono); }
.feature-card h3 { margin: auto 0 .6rem; font-size: 1.6rem; font-weight: 500; letter-spacing: -.035em; }
.feature-card p { color: var(--muted); }
.feature-card a { color: var(--bio); font: 700 .7rem var(--mono); }
.release-boundary { display: grid; grid-template-columns: .65fr 1fr; gap: clamp(2rem, 7vw, 7rem); background: linear-gradient(90deg, rgba(255, 23, 69, .035), transparent 60%); }
.release-boundary p { color: #bec1c8; font-size: 1.05rem; }
.boundary-note { padding: 1rem 1.2rem; border-left: 2px solid var(--amber); background: rgba(255, 198, 103, .045); }
.boundary-note strong { color: var(--amber); font: 700 .7rem var(--mono); text-transform: uppercase; letter-spacing: .07em; }
.boundary-note p { margin: .4rem 0 0; color: #c6c4bc; font-size: .88rem; }

.map-window { position: relative; display: block; overflow: hidden; min-height: 440px; border: 1px solid var(--line); background: radial-gradient(500px 250px at 55% 50%, rgba(115, 230, 174, .055), transparent), #040406; text-decoration: none; }
.map-window::before { position: absolute; inset: 0; content: ""; background-image: linear-gradient(rgba(85,216,255,.04) 1px, transparent 1px), linear-gradient(90deg,rgba(85,216,255,.04) 1px,transparent 1px); background-size: 44px 44px; }
.map-window svg { position: relative; width: 100%; min-width: 850px; padding: 2rem; transition: transform .3s ease; }
.map-window:hover svg { transform: scale(1.012); }
.map-window-label, .map-window-action { position: absolute; z-index: 2; padding: .65rem .8rem; background: #000; font: 700 .65rem var(--mono); text-transform: uppercase; letter-spacing: .08em; }
.map-window-label { left: 0; top: 0; color: var(--brand-bright); border-right: 1px solid var(--line); border-bottom: 1px solid var(--line); }
.map-window-action { right: 0; bottom: 0; color: var(--bio); border-left: 1px solid var(--line); border-top: 1px solid var(--line); }
.preview-cycle path { stroke: var(--bio); stroke-width: 2; stroke-dasharray: 4 9; filter: drop-shadow(0 0 8px rgba(115,230,174,.3)); }
.preview-routes path { stroke: var(--brand); stroke-width: 1.5; stroke-dasharray: 3 8; }
.preview-nodes circle { fill: #000; stroke: var(--bio); stroke-width: 2; }
.preview-nodes circle:nth-last-child(-n+4) { stroke: var(--brand); }
.preview-text { fill: var(--muted); font: 700 12px var(--mono); letter-spacing: 1px; }
.preview-text text:first-child { fill: var(--ink); font-size: 18px; }

.page-hero { width: min(100%, var(--max)); padding: clamp(5rem, 10vw, 9rem) clamp(1.25rem, 6vw, 6rem) clamp(3.5rem, 7vw, 6rem); margin: auto; border-bottom: 1px solid var(--line); }
.page-hero h1 { max-width: 1100px; overflow-wrap: anywhere; font-size: clamp(3.3rem, 8vw, 7.7rem); }
.page-hero > p { max-width: 860px; margin: 0; color: #b8bbc3; font-size: clamp(1.05rem, 1.8vw, 1.3rem); }
.status-banner { display: flex; flex-wrap: wrap; align-items: center; gap: .7rem 1.3rem; max-width: 760px; margin-top: 2rem; padding: .8rem 1rem; border: 1px solid var(--line); background: var(--surface); font: .7rem var(--mono); }
.status-banner strong { color: var(--bio); }.status-banner span:last-child { color: var(--muted); }.status-dot { width: 8px; height: 8px; border-radius: 50%; background: var(--amber); box-shadow: 0 0 12px rgba(255,198,103,.55); }

.family-layout { display: grid; grid-template-columns: minmax(0, 1fr) minmax(280px, 390px); gap: clamp(2.5rem, 7vw, 7rem); align-items: start; }
.prose { max-width: 820px; color: #c9cbd1; }
.prose h2, .record-main h2 { margin: 3rem 0 1rem; font-size: clamp(2rem, 4vw, 3.5rem); font-weight: 350; line-height: 1.08; letter-spacing: -.045em; color: var(--ink); }
.prose h2:first-child { margin-top: 0; }
.prose h3 { margin: 2.2rem 0 .6rem; color: var(--ink); font-size: 1.2rem; font-weight: 600; }
.prose li { margin-bottom: .5rem; }
.prose blockquote, .record-main blockquote { padding: 1.2rem 1.4rem; margin: 1rem 0 2rem; border-left: 2px solid var(--bio); background: rgba(115, 230, 174, .035); color: #d9dbdf; font-size: 1.05rem; }
.token-line { padding: .75rem 1rem; border: 1px solid rgba(115, 230, 174, .22); background: rgba(115, 230, 174, .035); color: var(--bio); font: 700 .77rem/1.8 var(--mono); }
.token-line.amber { border-color: rgba(255, 198, 103, .22); background: rgba(255, 198, 103, .035); color: var(--amber); }
.scope-panel { position: sticky; top: 100px; padding: 1.5rem; border: 1px solid var(--line); background: var(--surface); }
.scope-panel dl { margin: 1.5rem 0; }
.scope-panel dl div { padding: .75rem 0; border-bottom: 1px solid var(--line); }
.scope-panel dt, .fact-grid dt, .micro-meta dt, .record-aside dt, .measurement-panel dt { color: var(--dim); font: 650 .62rem var(--mono); text-transform: uppercase; letter-spacing: .07em; }
.scope-panel dd { margin: .2rem 0 0; overflow-wrap: anywhere; }
.scope-panel .button { width: 100%; }
.compact-section { padding-top: 4rem; padding-bottom: 5rem; }
.dossier-strip { display: grid; grid-template-columns: repeat(5, minmax(0, 1fr)); border-top: 1px solid var(--line); border-left: 1px solid var(--line); }
.dossier-strip a { display: grid; padding: 1rem; border-right: 1px solid var(--line); border-bottom: 1px solid var(--line); background: var(--surface); text-decoration: none; }
.dossier-strip strong { font-size: 1.2rem; }.dossier-strip span { color: var(--bio); font: .68rem var(--mono); }.dossier-strip small { color: var(--dim); font-size: .65rem; }

.filter-bar { display: grid; grid-template-columns: minmax(230px, 1.4fr) repeat(2, minmax(170px, .7fr)) auto auto; gap: .75rem; align-items: end; padding: 1rem; border: 1px solid var(--line); background: var(--surface); }
.filter-bar label, .compare-form label { display: grid; gap: .35rem; color: var(--brand-bright); font: 700 .62rem var(--mono); text-transform: uppercase; letter-spacing: .07em; }
.filter-bar input, .filter-bar select, .compare-form select, .search-form input { width: 100%; min-height: 44px; padding: .65rem .75rem; border: 1px solid var(--line); outline: 0; background: #020203; color: var(--ink); font: .83rem var(--sans); text-transform: none; letter-spacing: 0; }
.filter-bar input:focus, .filter-bar select:focus, .compare-form select:focus, .search-form input:focus { border-color: var(--brand); }
.filter-bar .text-link { min-height: 44px; display: grid; place-items: center; }
.result-count { margin: 1.1rem 0 1.6rem; color: var(--muted); font: .7rem var(--mono); }
.dossier-grid, .evidence-grid { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 1rem; }
.dossier-card, .evidence-card { display: flex; min-height: 390px; flex-direction: column; padding: 1.35rem; border: 1px solid var(--line); background: var(--surface); }
.dossier-card:hover, .evidence-card:hover { border-color: rgba(115, 230, 174, .35); background: linear-gradient(145deg, rgba(115,230,174,.035), var(--surface) 45%); }
.card-top { display: flex; justify-content: space-between; gap: .7rem; align-items: start; }
.card-top code { color: var(--dim); }
.status-tag { display: inline-flex; min-height: 24px; align-items: center; padding: .2rem .48rem; border: 1px solid rgba(85,216,255,.3); color: var(--cyan); font: 700 .58rem var(--mono); text-transform: uppercase; letter-spacing: .04em; }
.status-acatalytic-related { border-color: rgba(255,198,103,.4); color: var(--amber); }
.dossier-card h2, .evidence-card h2 { margin: 2rem 0 0; font-size: 2.3rem; font-weight: 350; line-height: 1; letter-spacing: -.05em; }
.dossier-card h2 a, .evidence-card h2 a { text-decoration: none; }
.protein-name { margin: .5rem 0; color: var(--bio); font-size: .82rem; }
.dossier-card > p:not(.protein-name), .evidence-card > p { color: var(--muted); font-size: .9rem; }
.micro-meta { display: grid; grid-template-columns: repeat(3, 1fr); gap: .5rem; padding-top: 1rem; margin: auto 0 1rem; border-top: 1px solid var(--line); }
.micro-meta dd { margin: .2rem 0 0; color: #c5c7cc; font-size: .73rem; overflow-wrap: anywhere; }
.card-link { color: var(--bio); font: 700 .68rem var(--mono); text-decoration: none; }
.empty-state { padding: clamp(2rem, 6vw, 5rem); border: 1px solid var(--line); background: radial-gradient(500px 250px at 50% 0, rgba(255,23,69,.06), transparent), var(--surface); text-align: center; }
.empty-state h2, .empty-state h3 { margin: .8rem auto; max-width: 720px; font-size: clamp(1.6rem, 4vw, 3rem); font-weight: 350; letter-spacing: -.04em; }
.empty-state p { max-width: 700px; margin: 0 auto 1.5rem; color: var(--muted); }
.inline-empty { padding: 2rem; text-align: left; }
.inline-empty h3, .inline-empty p { margin-left: 0; }
.empty-actions { display: flex; justify-content: center; flex-wrap: wrap; gap: .7rem; }

.record-hero { display: grid; grid-template-columns: 1fr auto; align-items: end; gap: 2rem; width: min(100%, var(--max)); padding: clamp(4rem, 9vw, 8rem) clamp(1.25rem, 6vw, 6rem) 3rem; margin: auto; border-bottom: 1px solid var(--line); }
.record-hero h1 { margin: 1.2rem 0 .4rem; font-size: clamp(4rem, 10vw, 8rem); }
.record-hero > div > p { margin: 0; color: var(--bio); font-size: 1.1rem; }
.back-link { display: inline-block; margin-bottom: 2rem; }
.identity-stamp { display: grid; min-width: 250px; padding: 1.2rem; border: 1px solid var(--line); background: var(--surface); }
.identity-stamp span { color: var(--amber); font: 700 .65rem var(--mono); text-transform: uppercase; }
.identity-stamp strong { margin: .5rem 0; color: var(--bio); font: 700 1.8rem var(--mono); }
.identity-stamp small { color: var(--muted); }
.record-layout { display: grid; grid-template-columns: minmax(0, 1fr) minmax(260px, 360px); gap: clamp(2.5rem, 7vw, 7rem); width: min(100%, var(--max)); padding: clamp(3.5rem, 8vw, 7rem) clamp(1.25rem, 6vw, 6rem); margin: auto; }
.record-main { max-width: 900px; }
.record-section + .record-section { padding-top: 1.5rem; margin-top: 4rem; border-top: 1px solid var(--line); }
.record-section h3 { margin: 2.2rem 0 .8rem; font-size: 1.15rem; font-weight: 650; letter-spacing: -.02em; }
.section-lede { max-width: 760px; color: var(--muted); font-size: 1rem; }
.fact-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); border-top: 1px solid var(--line); border-left: 1px solid var(--line); }
.fact-grid div { padding: 1rem; border-right: 1px solid var(--line); border-bottom: 1px solid var(--line); background: var(--surface); }
.fact-grid dd { margin: .3rem 0 0; overflow-wrap: anywhere; }
.fact-grid .fact-wide { grid-column: 1 / -1; }
.record-aside { display: grid; gap: 1rem; align-content: start; }
.record-aside section { padding: 1.2rem; border: 1px solid var(--line); background: var(--surface); }
.record-aside p { color: var(--muted); font-size: .83rem; }
.record-aside a { color: var(--bio); }
.source-chip { display: grid; margin-top: .8rem; padding: .75rem; border: 1px solid var(--line); text-decoration: none; }
.source-chip span { color: var(--muted); font: .68rem var(--mono); }
.tag-cloud { display: flex; flex-wrap: wrap; gap: .4rem; margin-top: .8rem; }
.tag-cloud span { padding: .3rem .45rem; border: 1px solid var(--line); color: var(--muted); font: .63rem var(--mono); }
.evidence-list { display: grid; gap: .6rem; }
.evidence-list a { display: grid; grid-template-columns: 10rem 1fr auto; gap: 1rem; padding: 1rem; border: 1px solid var(--line); text-decoration: none; }
.evidence-list span, .evidence-list small { color: var(--muted); font: .65rem var(--mono); }
.measurement-panel { padding: 1.2rem; border: 1px solid rgba(115,230,174,.25); background: rgba(115,230,174,.025); }
.measurement-panel dl { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); margin: 0; }
.measurement-panel dl div { padding: .8rem; border-bottom: 1px solid var(--line); }
.measurement-panel dd { margin: .25rem 0 0; overflow-wrap: anywhere; }
.detail-table { min-width: 760px; }
.detail-table small { display: block; margin-top: .35rem; color: var(--dim); }
.long-code, .digest { display: inline-block; max-width: 100%; overflow-wrap: anywhere; word-break: break-word; }
.refusal-callout { display: grid; gap: .55rem; padding: 1.2rem; margin: 1.25rem 0; border: 1px solid rgba(255,103,128,.34); background: rgba(255,103,128,.035); }
.refusal-callout strong { color: var(--danger); font: 700 .76rem/1.7 var(--mono); overflow-wrap: anywhere; }
.refusal-callout p { margin: 0; color: #c9b4b8; font-size: .88rem; }
.mini-refusal { padding: .55rem .65rem; border-left: 2px solid var(--danger); background: rgba(255,103,128,.035); color: #dcaeb6; font: 650 .63rem/1.6 var(--mono); overflow-wrap: anywhere; }
.source-description, .citation-panel { padding: 1rem 1.15rem; border: 1px solid var(--line); background: var(--surface); }
.source-description p, .citation-panel p { margin: .5rem 0 0; color: var(--muted); }
.citation-panel > strong { display: block; font-size: 1.05rem; line-height: 1.4; }
.citation-panel dl { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); margin: 1rem 0 0; border-top: 1px solid var(--line); border-left: 1px solid var(--line); }
.citation-panel dl div { padding: .75rem; border-right: 1px solid var(--line); border-bottom: 1px solid var(--line); }
.citation-panel dt { color: var(--dim); font: 650 .62rem var(--mono); text-transform: uppercase; }
.citation-panel dd { margin: .25rem 0 0; overflow-wrap: anywhere; }
.equation { font-family: var(--mono); overflow-wrap: anywhere; }
.evidence-crossrefs { margin-bottom: 1.4rem; }
.provenance-table td:nth-child(3) { min-width: 24rem; }

.map-hero { padding-bottom: 2.5rem; }
.compact-boundary { max-width: 900px; margin-top: 2rem; }
.map-shell { width: min(100%, 1680px); padding: 1.25rem clamp(.75rem, 2vw, 2rem) 3rem; margin: auto; }
.map-toolbar { display: flex; justify-content: space-between; gap: 1rem; padding: .7rem; border: 1px solid var(--line); border-bottom: 0; background: var(--surface); }
.route-filters, .zoom-controls { display: flex; flex-wrap: wrap; gap: .4rem; }
.route-filters button, .zoom-controls button { min-height: 38px; padding: .45rem .7rem; border: 1px solid var(--line); background: #020203; color: var(--muted); font: 650 .63rem var(--mono); text-transform: uppercase; }
.route-filters button:hover, .zoom-controls button:hover, .route-filters button.is-active { border-color: var(--brand); color: #fff; }
.route-filters button.is-active { background: rgba(255,23,69,.12); }
.map-layout { display: grid; grid-template-columns: minmax(0, 1fr) 330px; border: 1px solid var(--line); }
.map-region { min-width: 0; overflow: auto; background: #020304; overscroll-behavior-inline: contain; scrollbar-color: var(--brand) #111; }
.scroll-cue { display: none; margin: .65rem; color: var(--bio); font: .65rem var(--mono); }
.pathway-svg { min-width: 1040px; width: 100%; cursor: grab; touch-action: pan-x pan-y; user-select: none; background-image: linear-gradient(rgba(85,216,255,.026) 1px, transparent 1px), linear-gradient(90deg,rgba(85,216,255,.026) 1px,transparent 1px); background-size: 40px 40px; }
.pathway-svg.is-dragging { cursor: grabbing; }
.compartments rect { fill: rgba(5,7,8,.78); stroke: rgba(85,216,255,.18); stroke-width: 1; }
.compartments text { fill: rgba(85,216,255,.65); font: 700 12px var(--mono); letter-spacing: 2px; }
.membrane-line { stroke: rgba(85,216,255,.28); stroke-width: 3; stroke-dasharray: 5 10; }.compartments .membrane-label { fill: rgba(85,216,255,.38); font-size: 9px; }
.map-reaction { cursor: pointer; transition: opacity .16s ease; }
.map-reaction path { fill: none; stroke: var(--bio); stroke-width: 2.2; marker-end: url(#arrow); }
.arrow-head { fill: var(--bio); fill: context-stroke; }
.map-reaction path.substrate-link { stroke-width: 1.2; stroke-dasharray: 3 6; }
.map-reaction text { fill: #c1c5c9; font: 700 10px var(--mono); letter-spacing: .5px; paint-order: stroke; stroke: #020304; stroke-width: 4px; }
.map-reaction:hover path, .map-reaction:focus path, .map-reaction.is-selected path { stroke: var(--brand-bright); filter: drop-shadow(0 0 6px rgba(255,23,69,.55)); }
.map-reaction:hover text, .map-reaction:focus text, .map-reaction.is-selected text { fill: #fff; }
.map-reaction.is-collapsed path { stroke-dasharray: 8 8; }
.map-reaction.is-segmented path { stroke-dasharray: 20 5 4 5; }
.map-reaction.is-transport path { stroke-dasharray: 2 9; stroke-linecap: round; }
.map-reaction.is-transport path.exchange-return { marker-end: url(#arrow); }
.map-reaction.is-pale path { stroke: rgba(173, 136, 255, .62); stroke-width: 1.5; }
.map-reaction.is-secondary path { stroke: var(--amber); stroke-dasharray: 4 5; }
.route-carbon-gate path { stroke: var(--cyan); }.route-cataplerosis path { stroke: var(--brand-bright); }.route-oxalosuccinate path { stroke: var(--violet); stroke-width: 3; }.route-amino-entry path, .route-propionyl-entry path { stroke: var(--amber); }
.context-link path { fill: none; stroke: rgba(167,171,181,.25); stroke-dasharray: 2 9; }.context-link text { fill: var(--dim); font: 600 9px var(--mono); }
.context-omission text { fill: var(--amber); font: 650 8px var(--mono); letter-spacing: .4px; paint-order: stroke; stroke: #020304; stroke-width: 3px; }
.mechanistic-inset > rect { fill: rgba(173,136,255,.025); stroke: rgba(173,136,255,.32); stroke-dasharray: 3 5; }
.mechanistic-inset .inset-title { fill: rgba(215,200,255,.75); font: 700 8px var(--mono); letter-spacing: .8px; }
.metabolites rect { fill: #050708; stroke: rgba(115,230,174,.43); stroke-width: 1; }
.metabolites text { fill: #e6ece8; font: 700 10px var(--mono); text-anchor: middle; letter-spacing: .4px; }
.metabolites .featured-metabolite rect { stroke: var(--violet); stroke-width: 2; filter: url(#soft-glow); }
.metabolites .featured-metabolite text { fill: #e0d5ff; }.metabolites .featured-metabolite .subtext { fill: var(--violet); font-size: 7px; }
.map-reaction[hidden] { display: none; }
.map-inspector { padding: 1.35rem; border-left: 1px solid var(--line); background: var(--surface); }
.map-inspector h2 { margin: .7rem 0; font-size: 1.7rem; font-weight: 420; line-height: 1.12; letter-spacing: -.035em; }
.map-inspector > p { color: var(--muted); font-size: .84rem; overflow-wrap: anywhere; }
.map-inspector dl { margin: 1.3rem 0; border-top: 1px solid var(--line); }
.map-inspector dl div { padding: .7rem 0; border-bottom: 1px solid var(--line); }
.map-inspector dt { color: var(--dim); font: .62rem var(--mono); text-transform: uppercase; }.map-inspector dd { margin: .2rem 0 0; font-size: .82rem; }
.map-inspector [data-map-human] { display: flex; flex-wrap: wrap; gap: .25rem .5rem; }
.map-inspector [data-map-human] a { color: var(--cyan); font: .68rem var(--mono); }
.map-inspector .button { width: 100%; }
.map-legend { display: flex; flex-wrap: wrap; gap: 1rem 2rem; padding: .8rem 1rem; border: 1px solid var(--line); border-top: 0; color: var(--muted); font: .65rem var(--mono); }
.map-legend span { display: flex; align-items: center; gap: .5rem; }.map-legend i { display: inline-block; width: 30px; height: 9px; }.legend-solid { border-top: 2px solid var(--bio); }.legend-segmented { height: 3px !important; background: repeating-linear-gradient(90deg,var(--bio) 0 9px,transparent 9px 12px,var(--bio) 12px 15px,transparent 15px 19px); }.legend-dashed { border-top: 2px dashed var(--bio); }.legend-dotted { border-top: 2px dotted var(--bio); }.legend-node { border: 1px solid var(--bio); }.legend-feature { border: 2px solid var(--violet); box-shadow: 0 0 8px rgba(173,136,255,.35); }
.topology-disclosure { display: flex; gap: .7rem; padding: .85rem 1rem; border: 1px solid rgba(255,198,103,.35); border-bottom: 0; background: rgba(255,198,103,.045); font-size: .82rem; }
.topology-disclosure strong { flex: 0 0 auto; color: var(--amber); font: 800 .7rem var(--mono); text-transform: uppercase; }
.topology-disclosure span { color: #cbc7bc; }
.map-name-note { display: grid; grid-template-columns: .7fr 1fr; gap: clamp(2rem, 7vw, 7rem); }
.map-name-note h2 { margin: .7rem 0; font-size: clamp(2.2rem, 5vw, 4.5rem); font-weight: 320; line-height: 1.02; letter-spacing: -.055em; }
.map-name-note p { color: var(--muted); }
.snapshot-strip { display: flex; flex-wrap: wrap; gap: .5rem 1.5rem; padding: .8rem 1rem; border: 1px solid var(--line); border-bottom: 0; background: var(--surface); color: var(--muted); font: .66rem var(--mono); }
.snapshot-strip strong { color: var(--bio); }
.table-region { max-width: 100%; overflow-x: auto; border: 1px solid var(--line); background: var(--surface); scrollbar-color: var(--brand) #111; }
table { width: 100%; min-width: 900px; border-collapse: collapse; font-size: .82rem; }
caption { padding: .9rem; border-bottom: 1px solid var(--line); color: var(--muted); text-align: left; }
th, td { padding: 1rem; border-right: 1px solid var(--line); border-bottom: 1px solid var(--line); text-align: left; vertical-align: top; }
thead th { background: var(--surface-soft); color: var(--brand-bright); font: 700 .65rem var(--mono); text-transform: uppercase; letter-spacing: .05em; }
tbody th { color: var(--ink); font-weight: 600; } tbody th small { display: block; margin-top: .4rem; color: var(--dim); font-size: .66rem; font-weight: 400; } tbody td { color: #b9bcc3; }

.comparison-shell { display: grid; gap: 3rem; }
.comparison-picker, .fixture-picker { padding: 1.5rem; border: 1px solid var(--line); background: var(--surface); }
.comparison-picker h2, .fixture-picker h2 { margin: .6rem 0 1.4rem; font-size: clamp(1.7rem, 3vw, 2.6rem); }
.compare-form { display: grid; grid-template-columns: 1fr 1fr auto; gap: .75rem; align-items: end; }
.fixture-grid { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: 1px; background: var(--line); border: 1px solid var(--line); }
.fixture-grid a { display: grid; min-height: 150px; align-content: end; padding: 1rem; background: #050507; text-decoration: none; }
.fixture-grid a:hover, .fixture-grid a[aria-current="true"] { background: rgba(255,23,69,.07); }.fixture-grid strong { color: var(--bio); }.fixture-grid span { margin-top: .45rem; color: var(--muted); font-size: .78rem; }
.decision-panel { padding: clamp(1.5rem, 4vw, 3rem); border: 1px solid var(--line); background: var(--surface); }
.decision-allowed { border-color: rgba(115,230,174,.4); }.decision-refused { border-color: rgba(255,103,128,.42); }
.decision-head { display: flex; gap: 1.2rem; align-items: center; }.decision-head h2 { margin: .4rem 0; }.decision-head p { margin: 0; color: var(--muted); }
.decision-mark { display: grid; flex: 0 0 64px; width: 64px; height: 64px; place-items: center; border: 1px solid currentColor; color: var(--danger); font: 300 2.5rem var(--sans); }
.decision-allowed .decision-mark { color: var(--bio); }
.measurement-pair { display: grid; grid-template-columns: 1fr 1fr; gap: 1px; margin: 2rem 0; background: var(--line); border: 1px solid var(--line); }
.measurement-pair article { padding: 1rem; background: #030304; }.measurement-pair span { color: var(--dim); font: .62rem var(--mono); }.measurement-pair strong { display: block; margin: .45rem 0; color: var(--bio); }.measurement-pair p { margin: 0; color: var(--muted); font: .72rem var(--mono); }
.refusal-list { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: .75rem; }
.refusal-list article { padding: 1rem; border: 1px solid rgba(255,103,128,.2); background: rgba(255,103,128,.025); }.refusal-list code { color: var(--danger); font-weight: 700; }.refusal-list h3 { margin: .7rem 0 .3rem; font-size: 1rem; }.refusal-list p { margin: 0; color: var(--muted); font-size: .82rem; }.refusal-list small { display: block; margin-top: .7rem; color: #c5adb1; }
.principle-list { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 1px; padding: 1px; counter-reset: principle; list-style: none; background: var(--line); }
.principle-list li { position: relative; padding: 1.2rem 1.2rem 1.2rem 3.5rem; background: var(--surface); counter-increment: principle; }.principle-list li::before { position: absolute; left: 1rem; color: var(--brand); content: counter(principle, decimal-leading-zero); font: 700 .7rem var(--mono); }

.source-shell { display: grid; gap: 1rem; }
.source-record { display: grid; grid-template-columns: 7rem 1fr; gap: 2rem; padding: clamp(1.5rem, 4vw, 3rem); border: 1px solid var(--line); background: var(--surface); scroll-margin-top: 100px; }
.source-index { color: var(--brand); font: 700 1rem var(--mono); text-transform: uppercase; }.source-record h2 { margin: .5rem 0; font-size: 2.6rem; font-weight: 350; letter-spacing: -.045em; }.source-record p { color: var(--muted); }
.source-record dl { display: grid; grid-template-columns: repeat(5, minmax(0, 1fr)); border-top: 1px solid var(--line); border-left: 1px solid var(--line); }.source-record dl div { padding: .8rem; border-right: 1px solid var(--line); border-bottom: 1px solid var(--line); }.source-record dt { color: var(--dim); font: .62rem var(--mono); text-transform: uppercase; }.source-record dd { margin: .25rem 0 0; overflow-wrap: anywhere; font-size: .77rem; }
.source-actions { display: flex; flex-wrap: wrap; gap: .6rem; margin-top: 1rem; }.source-boundary { margin-top: 2rem; }
.license-snapshot { padding: .85rem 1rem; margin-top: 1rem; border-left: 2px solid var(--bio); background: rgba(115,230,174,.025); }
.license-snapshot strong { color: var(--bio); font: 700 .65rem var(--mono); text-transform: uppercase; }
.license-snapshot p { margin: .35rem 0 0; font: .68rem/1.6 var(--mono); overflow-wrap: anywhere; }

.method-shell { display: grid; grid-template-columns: 220px minmax(0, 1fr); gap: clamp(3rem, 8vw, 8rem); width: min(100%, var(--max)); padding: clamp(4rem, 8vw, 7rem) clamp(1.25rem, 6vw, 6rem); margin: auto; }
.method-rail { position: sticky; top: 100px; display: grid; align-self: start; }.method-rail a { padding: .65rem 0; border-bottom: 1px solid var(--line); color: var(--muted); font: .68rem var(--mono); text-decoration: none; }.method-rail a:hover { color: var(--bio); }
.method-prose { max-width: 940px; }.method-prose section { padding: 1rem 0 3rem; scroll-margin-top: 100px; border-bottom: 1px solid var(--line); }.method-prose section:first-child { padding-top: 0; }
.policy-code-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: .6rem; margin-top: 2rem; }.policy-code-grid article { padding: .9rem; border: 1px solid var(--line); background: var(--surface); }.policy-code-grid code { color: var(--brand-bright); font-weight: 700; }.policy-code-grid p { margin: .5rem 0; font-size: .82rem; }.policy-code-grid small { color: var(--dim); }

.download-grid { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 1px; padding: 1px; background: var(--line); }.download-grid article { display: flex; min-height: 420px; flex-direction: column; padding: 1.5rem; background: var(--surface); }.file-type { color: var(--brand-bright); font: 700 .65rem var(--mono); text-transform: uppercase; }.download-grid h2 { margin: 2.5rem 0 .6rem; font-size: 2rem; font-weight: 400; letter-spacing: -.04em; }.download-grid p { color: var(--muted); }.download-grid dl { margin: auto 0 1.2rem; }.download-grid dl div { display: flex; justify-content: space-between; gap: 1rem; padding: .55rem 0; border-bottom: 1px solid var(--line); }.download-grid dt { color: var(--dim); font: .63rem var(--mono); }.download-grid dd { margin: 0; font-size: .72rem; }.license-matrix { margin-top: 5rem; }.license-matrix h2 { font-size: clamp(2rem, 4vw, 3.5rem); font-weight: 350; letter-spacing: -.045em; }

.timeline { position: relative; max-width: 1100px; }.timeline::before { position: absolute; left: calc(clamp(1.25rem, 5vw, 5rem) + 120px); top: 6rem; bottom: 6rem; width: 1px; content: ""; background: var(--line); }.timeline article { position: relative; display: grid; grid-template-columns: 120px 1fr; gap: 3rem; padding: 2rem 0 3rem; }.timeline-date { display: grid; align-content: start; }.timeline-date::after { position: absolute; left: 115px; top: 2.35rem; width: 11px; height: 11px; content: ""; border: 2px solid var(--brand); border-radius: 50%; background: #000; box-shadow: 0 0 13px rgba(255,23,69,.4); }.timeline-date strong { font: .75rem var(--mono); }.timeline-date span { color: var(--dim); font: .65rem var(--mono); }.timeline article h2 { margin: .55rem 0; font-size: 2rem; font-weight: 400; }.timeline article p { color: var(--muted); }

.search-hero { padding-bottom: 3rem; }.search-form { max-width: 900px; margin-top: 2.3rem; }.search-form label { display: block; margin-bottom: .5rem; color: var(--brand-bright); font: 700 .68rem var(--mono); }.search-form > div { display: flex; }.search-form input { min-height: 52px; font-size: 1rem; }.search-form .button { min-width: 130px; }
.search-results { padding-top: 2rem; }.result-list { display: grid; gap: .65rem; }.result-list a { display: grid; grid-template-columns: 9rem 1fr auto; gap: .4rem 1.2rem; padding: 1rem; border: 1px solid var(--line); background: var(--surface); text-decoration: none; }.result-list a > span { grid-row: 1 / 3; color: var(--brand-bright); font: .65rem var(--mono); }.result-list strong { font-size: 1.05rem; }.result-list p { margin: 0; color: var(--muted); font-size: .82rem; }.result-list small { grid-column: 3; grid-row: 1 / 3; align-self: center; color: var(--bio); font: .65rem var(--mono); }

.legal { max-width: 900px; }.legal h2 { font-size: 2rem; }.error-page { display: grid; min-height: 70svh; place-content: center; padding: 3rem 1.25rem; text-align: center; }.error-code { color: rgba(255,23,69,.2); font: 300 clamp(6rem, 18vw, 14rem)/.8 var(--sans); }.error-page h1 { max-width: 900px; margin: 1rem auto; font-size: clamp(2.5rem, 7vw, 6rem); }.error-page p { max-width: 650px; margin: 0 auto 2rem; color: var(--muted); }.error-page > div { display: flex; justify-content: center; gap: .6rem; flex-wrap: wrap; }

.site-foot { border-top: 1px solid var(--line); background: linear-gradient(180deg, rgba(17,31,26,.8), var(--field-deep)); }.foot-grid { display: grid; grid-template-columns: 1.5fr .7fr .7fr; gap: 3rem; width: min(100%, var(--max)); padding: 3rem clamp(1.25rem, 5vw, 5rem); margin: auto; }.foot-grid strong { font-size: 1.3rem; }.foot-grid p { max-width: 540px; color: var(--muted); font-size: .83rem; }.foot-grid nav { display: grid; align-content: start; gap: .5rem; }.foot-grid nav a { color: var(--muted); font: .68rem var(--mono); }.foot-note { width: min(100%, var(--max)); padding: 1rem clamp(1.25rem, 5vw, 5rem); margin: auto; border-top: 1px solid var(--line); color: var(--dim); font: .6rem/1.6 var(--mono); }

@media (min-width: 1181px) and (max-width: 1399px) {
  .head-inner { grid-template-columns: auto 1fr auto; }
  .desktop-nav { display: none; }
  .mobile-nav { display: block; }
  .mobile-nav summary { min-height: 40px; padding: .6rem .8rem; border: 1px solid var(--line); color: var(--ink); font: 700 .68rem var(--mono); list-style: none; cursor: pointer; }
  .mobile-nav summary::-webkit-details-marker { display: none; }
  .mobile-nav[open] nav { position: fixed; right: max(1rem, calc((100vw - var(--max)) / 2 + 1rem)); top: 74px; display: block; width: min(420px, calc(100vw - 2rem)); max-height: calc(100dvh - 86px); overflow: auto; padding: .75rem; border: 1px solid var(--line-strong); border-radius: 0 0 18px 18px; background: rgba(10, 20, 17, .98); box-shadow: 0 28px 80px rgba(0,0,0,.52); backdrop-filter: blur(22px); }
  .mobile-nav nav a { display: flex; min-height: 44px; align-items: center; padding: .65rem; border-bottom: 1px solid var(--line); color: var(--muted); font: .72rem var(--sans); text-decoration: none; }
  .mobile-nav nav a[aria-current="page"] { color: var(--bio); }
}

@media (max-width: 1180px) {
  .head-inner { grid-template-columns: auto 1fr auto; }
  .desktop-nav { display: none; }
  .mobile-nav { display: block; }
  .mobile-nav summary { min-height: 40px; padding: .6rem .8rem; border: 1px solid var(--line); color: var(--ink); font: 700 .68rem var(--mono); list-style: none; cursor: pointer; }
  .mobile-nav summary::-webkit-details-marker { display: none; }
  .mobile-nav[open] nav { position: fixed; right: max(1rem, calc((100vw - var(--max)) / 2 + 1rem)); top: 74px; display: block; width: min(420px, calc(100vw - 2rem)); max-height: calc(100dvh - 86px); overflow: auto; padding: .75rem; border: 1px solid var(--line-strong); border-radius: 0 0 18px 18px; background: rgba(10, 20, 17, .98); box-shadow: 0 28px 80px rgba(0,0,0,.52); backdrop-filter: blur(22px); }
  .mobile-nav nav a { display: flex; min-height: 44px; align-items: center; padding: .65rem; border-bottom: 1px solid var(--line); color: var(--muted); font: .72rem var(--sans); text-decoration: none; }
  .mobile-nav nav a[aria-current="page"] { color: var(--bio); }
  .hero { grid-template-columns: 1fr; min-height: auto; }.hero-instrument { max-width: 720px; }
  .dossier-grid, .evidence-grid { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  .dossier-strip { grid-template-columns: repeat(3, minmax(0, 1fr)); }
  .map-layout { grid-template-columns: 1fr; }.map-inspector { border-left: 0; border-top: 1px solid var(--line); }
  .source-record dl { grid-template-columns: repeat(3, minmax(0, 1fr)); }
  .fixture-grid { grid-template-columns: repeat(2, minmax(0, 1fr)); }
}

@media (max-width: 800px) {
  .head-inner { min-height: 66px; gap: .7rem; }.head-search { display: none; }.brand-copy span { display: none; }
  .mobile-nav[open] nav { top: 66px; right: .5rem; width: calc(100vw - 1rem); max-height: calc(100dvh - 72px); border-radius: 0 0 16px 16px; }
  .hero { padding-top: 4rem; padding-bottom: 5rem; }.hero-copy h1 { font-size: clamp(3.5rem, 17vw, 6rem); }.signal-row { grid-template-columns: 1fr; }.signal-row div { padding-left: 0; border-right: 0; border-bottom: 1px solid var(--line); }
  .split-heading, .release-boundary, .family-layout, .record-hero, .record-layout, .method-shell, .map-name-note { grid-template-columns: 1fr; }.split-heading p { padding: 1rem 0 0; border-left: 0; border-top: 1px solid var(--brand); }
  .three-grid, .download-grid { grid-template-columns: 1fr; }.feature-card { min-height: 260px; }.release-boundary { gap: 1rem; }
  .map-window { min-height: 340px; overflow-x: auto; }.map-window svg { min-width: 780px; }
  .scope-panel, .method-rail { position: static; }.dossier-strip { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  .filter-bar { grid-template-columns: 1fr 1fr; }.filter-bar label:first-child { grid-column: 1 / -1; }
  .dossier-grid, .evidence-grid { grid-template-columns: 1fr; }.dossier-card, .evidence-card { min-height: 340px; }
  .record-hero { align-items: start; }.identity-stamp { min-width: 0; }.fact-grid, .measurement-panel dl, .citation-panel dl { grid-template-columns: 1fr; }.fact-grid .fact-wide { grid-column: auto; }
  .evidence-list a { grid-template-columns: 1fr; gap: .35rem; }.evidence-list a > * { overflow-wrap: anywhere; }
  .scroll-cue { display: block; }.map-toolbar { align-items: start; flex-direction: column; }.map-shell { padding-inline: 0; }.map-toolbar, .map-inspector, .map-legend { border-inline: 0; }.map-layout { border-inline: 0; }
  .compare-form { grid-template-columns: 1fr; }.measurement-pair, .refusal-list, .principle-list, .policy-code-grid { grid-template-columns: 1fr; }
  .source-record { grid-template-columns: 1fr; gap: .5rem; }.source-record dl { grid-template-columns: repeat(2, minmax(0, 1fr)); }.source-index { opacity: .6; }
  .method-rail { grid-template-columns: repeat(2, minmax(0, 1fr)); }.method-rail a { padding-right: .5rem; }
  .timeline::before { display: none; }.timeline article { grid-template-columns: 1fr; gap: .5rem; }.timeline-date::after { display: none; }
  .result-list a { grid-template-columns: 1fr; }.result-list a > span, .result-list small { grid-column: 1; grid-row: auto; }
  .foot-grid { grid-template-columns: 1fr 1fr; }.foot-grid > div:first-child { grid-column: 1 / -1; }
}

@media (max-width: 520px) {
  body { font-size: 15px; }.brand-mark { width: 34px; height: 34px; }.brand-mark img { width: 30px; height: 30px; }.brand-copy strong { font-size: .9rem; }
  .page-hero h1 { font-size: clamp(3rem, 16vw, 5rem); }.page-hero, .feature-section, .content-shell, .index-shell, .source-shell, .download-shell, .comparison-shell, .search-results, .legal, .timeline { padding-left: 1rem; padding-right: 1rem; }
  .filter-bar { grid-template-columns: 1fr; }.filter-bar label:first-child { grid-column: auto; }.micro-meta { grid-template-columns: 1fr 1fr; }
  .dossier-strip { grid-template-columns: 1fr 1fr; }.fixture-grid { grid-template-columns: 1fr; }.source-record dl { grid-template-columns: 1fr; }
  .search-form > div { display: grid; }.search-form .button { width: 100%; }.foot-grid { grid-template-columns: 1fr; }.foot-grid > div:first-child { grid-column: auto; }
}

@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
  *, *::before, *::after { scroll-behavior: auto !important; transition-duration: .001ms !important; animation-duration: .001ms !important; animation-iteration-count: 1 !important; }
}

@media (forced-colors: active) {
  .status-dot, .instrument-core span { forced-color-adjust: none; }
  .map-reaction path, .metabolites rect { stroke: CanvasText; }
  .button, .feature-card, .dossier-card, .evidence-card, .source-record { border-color: CanvasText; }
}