Source assertion

ChEMBL direct single-protein activity record with source-reported and source-standardized lexical values preserved.

Evidence ID: ACTIVITY:ChEMBL_37:18164781
Subject dossier: ca11
Source chain: uniprot + chembl
Upstream record: 18164781
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: Admitted release record

Lossless activity measurement

Source-reported value: = 6.9 nM
Source-standardized value: = 6.9 nM
Reported endpoint: Ki
Standardized endpoint: Ki
Reported upper bound: not reported in admitted source fields
Reported text value: not reported in admitted source fields
Standardization flag: 1
pChEMBL from source: 8.16

Reported and source-standardized fields are displayed separately and retain their exact lexical values. The standardized field does not overwrite the upstream report.

Record-local comparison refusalCATALYTIC_STATUS_MISMATCH · CONDITION_MISSING

No cross-assay comparison is authorized by this record. Evaluate target, construct, endpoint, relation, units, assay format, conditions, and exact molecular form first.

Catalytic-status interpretation boundary

The protein dossier is classified as acatalytic related. This ChEMBL activity remains admitted as a source-reported experimental record, but it does not reclassify the protein as catalytic or authorize ranking it against catalytic paralogs.

Assay and target

ChEMBL activity: 18164781
Target: CHEMBL2420 · SINGLE PROTEIN
Assay: CHEMBL4036367 · Binding (B)
BAO format: BAO_0000019 · assay format
BAO endpoint: BAO_0000192
Target confidence: 9 · Direct single protein target assigned
Source quality flags: potential_duplicate=0 · data_validity_comment=not reported in admitted source fields

Upstream assay description

Inhibition of recombinant human membrane bound carbonic anhydrase 11 expressed in Escherichia coli pretreated for 15 mins prior to testing by stopped-flow assay

Compound identity

Molecule: CHEMBL4091812 · not reported in admitted source fields
Parent form: CHEMBL4091812 · is_parent_form=true
Molecule type: Small molecule
Chirality source code: -1
Standard InChIKey: SEGXUNJRVJCXMH-UHFFFAOYSA-N
Canonical SMILES: NS(=O)(=O)c1ccc(NC(=S)N/N=C2\C(=O)Nc3ccccc32)cc1
Standard InChI: InChI=1S/C15H13N5O3S2/c16-25(22,23)10-7-5-9(6-8-10)17-15(24)20-19-13-11-3-1-2-4-12(11)18-14(13)21/h1-8H,(H2,16,22,23)(H2,17,20,24)(H,18,19,21)

Document

Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases.

Karalı N, Akdemir A, Göktaş F, Eraslan Elma P, Angeli A, Kızılırmak M, Supuran CT.

ChEMBL document: CHEMBL4033724
Journal / year: Bioorg Med Chem · 2017
DOI: 10.1016/j.bmc.2017.05.029
PubMed: 28545816

Comparison state

Prequalified: No — pairwise evaluation is still required
Protein identity: O75493 · taxon 9606
Variant / construct: not reported in admitted source fields / not reported in admitted source fields
Conditions: pH not reported in admitted source fields · temperature not reported in admitted source fields °C · substrate not reported in admitted source fields · buffer not reported in admitted source fields

Snapshot provenance

Each retained corpus build input is identified by retrieval time, snapshot path, SHA-256 digest, and exact upstream request. The snapshot files are not embedded in the served binary; the provenance identifiers remain dependencies of this one admitted record, not interchangeable citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:33Z	`raw/uniprot/entries/O75493.json`	`1c27d284e17a666e94656536119b00789c29f98abb86ee46caf2abcdba8a01c0`	Open exact source
2026-07-14T09:22:20Z	`raw/chembl/targets/CHEMBL2420.json`	`3b55a351a51ea152bc923f22a2c49d02ffbd89b2057015c5cdb57de2c826ba59`	Open exact source
2026-07-14T09:22:42Z	`raw/chembl/direct-assays/CHEMBL2420.json`	`a214f4d8db9b267940d0b2ce7bad920c51e2193c0bd5c90ce20eed5015514428`	Open exact source
2026-07-14T09:23:07Z	`raw/chembl/assay-activities/CHEMBL4036367.json`	`c8f850bc9ea6769a987bbb89aabfd57a6994d5479ad9b55ac7a2e869a9b24bf1`	Open exact source
2026-07-14T09:23:27Z	`raw/chembl/activities/18164781.json`	`62e24e13705732474907b616b802d79a79a136ee1da7941fe2a13fe3102da561`	Open exact source
2026-07-14T09:23:27Z	`raw/chembl/assays/CHEMBL4036367.json`	`a342ee27c2cd54bc78c097f2fd383182d04c17498d88ecb86587e639b6fafbcb`	Open exact source
2026-07-14T09:23:27Z	`raw/chembl/molecules/CHEMBL4091812.json`	`d3aeba8dc06cd335e037d8ae3409ab1aeff2e9fb02e6aad8961d9690e02332cd`	Open exact source
2026-07-14T09:23:27Z	`raw/chembl/documents/CHEMBL4033724.json`	`6ae6ac90ae83633c9e226574fab346c95aa542cd2e88a8779e3adca46ced9942`	Open exact source