Assay activity
2259029CA1 · ChEMBL activity 2259029
IC50 source measurement: = 3.04 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Evidence records
120 admitted records: 80 experimental structure mappings, 28 direct assay activities, and 12 protein-specific reaction assignments. Every record keeps multi-source provenance and, where applicable, lossless measurement text. Automated release checks passed; independent biochemical review remains pending.
120 admitted evidence records in this view.
Assay activity
2259048CA1 · ChEMBL activity 2259048
Ki source measurement: = 6.87 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
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1AZMCA1 · PDB 1AZM
X-ray diffraction structure mapped through PDBe/SIFTS.
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1BZMCA1 · PDB 1BZM
X-ray diffraction structure mapped through PDBe/SIFTS.
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1CRMCA1 · PDB 1CRM
X-ray diffraction structure mapped through PDBe/SIFTS.
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1HCBCA1 · PDB 1HCB
X-ray diffraction structure mapped through PDBe/SIFTS.
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1J9WCA1 · PDB 1J9W
X-ray diffraction structure mapped through PDBe/SIFTS.
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2FOYCA1 · PDB 2FOY
X-ray diffraction structure mapped through PDBe/SIFTS.
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2NMXCA1 · PDB 2NMX
X-ray diffraction structure mapped through PDBe/SIFTS.
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3W6HCA1 · PDB 3W6H
X-ray diffraction structure mapped through PDBe/SIFTS.
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5E2MCA1 · PDB 5E2M
X-ray diffraction structure mapped through PDBe/SIFTS.
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6F3BCA1 · PDB 6F3B
X-ray diffraction structure mapped through PDBe/SIFTS.
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RHEA:10748CA1 · RHEA:10748 assignment
Protein-specific UniProt catalytic-activity assignment joined to a balanced Rhea master reaction.
Inspect full recordAssay activity
18164781CA11 · ChEMBL activity 18164781
Ki source measurement: = 6.9 nM. No cross-assay comparison is prequalified.
Comparison refused · CATALYTIC_STATUS_MISMATCH, CONDITION_MISSING
Inspect full record Assay activity
1980545CA11 · ChEMBL activity 1980545
Kinact source measurement: = 5.7 nM. No cross-assay comparison is prequalified.
Comparison refused · CATALYTIC_STATUS_MISMATCH, CONDITION_MISSING
Inspect full record Assay activity
2456870CA12 · ChEMBL activity 2456870
Kinact source measurement: = 7.79 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
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2619636CA12 · ChEMBL activity 2619636
Ki source measurement: = 0.39 nM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
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1JCZCA12 · PDB 1JCZ
X-ray diffraction structure mapped through PDBe/SIFTS.
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1JD0CA12 · PDB 1JD0
X-ray diffraction structure mapped through PDBe/SIFTS.
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4HT2CA12 · PDB 4HT2
X-ray diffraction structure mapped through PDBe/SIFTS.
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4KP5CA12 · PDB 4KP5
X-ray diffraction structure mapped through PDBe/SIFTS.
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4KP8CA12 · PDB 4KP8
X-ray diffraction structure mapped through PDBe/SIFTS.
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4Q0LCA12 · PDB 4Q0L
X-ray diffraction structure mapped through PDBe/SIFTS.
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6R71CA12 · PDB 6R71
X-ray diffraction structure mapped through PDBe/SIFTS.
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6RPSCA12 · PDB 6RPS
X-ray diffraction structure mapped through PDBe/SIFTS.
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RHEA:10748CA12 · RHEA:10748 assignment
Protein-specific UniProt catalytic-activity assignment joined to a balanced Rhea master reaction.
Inspect full recordAssay activity
2949458CA13 · ChEMBL activity 2949458
Ki source measurement: = 32.0 nM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Assay activity
3380039CA13 · ChEMBL activity 3380039
Ki source measurement: = 79.0 nM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Experimental structure
3CZVCA13 · PDB 3CZV
X-ray diffraction structure mapped through PDBe/SIFTS.
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3D0NCA13 · PDB 3D0N
X-ray diffraction structure mapped through PDBe/SIFTS.
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3DA2CA13 · PDB 3DA2
X-ray diffraction structure mapped through PDBe/SIFTS.
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4HU1CA13 · PDB 4HU1
X-ray diffraction structure mapped through PDBe/SIFTS.
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4KNMCA13 · PDB 4KNM
X-ray diffraction structure mapped through PDBe/SIFTS.
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4KNNCA13 · PDB 4KNN
X-ray diffraction structure mapped through PDBe/SIFTS.
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5OGJCA13 · PDB 5OGJ
X-ray diffraction structure mapped through PDBe/SIFTS.
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RHEA:10748CA13 · RHEA:10748 assignment
Protein-specific UniProt catalytic-activity assignment joined to a balanced Rhea master reaction.
Inspect full recordAssay activity
2456872CA14 · ChEMBL activity 2456872
Kinact source measurement: = 8.59 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Assay activity
2619658CA14 · ChEMBL activity 2619658
Ki source measurement: = 6.5 nM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Experimental structure
4LU3CA14 · PDB 4LU3
X-ray diffraction structure mapped through PDBe/SIFTS.
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5CJFCA14 · PDB 5CJF
X-ray diffraction structure mapped through PDBe/SIFTS.
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RHEA:10748CA14 · RHEA:10748 assignment
Protein-specific UniProt catalytic-activity assignment joined to a balanced Rhea master reaction.
Inspect full recordAssay activity
2259038CA2 · ChEMBL activity 2259038
IC50 source measurement: = 4.49 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Assay activity
2259058CA2 · ChEMBL activity 2259058
Ki source measurement: = 8.72 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Assay activity
2259064CA2 · ChEMBL activity 2259064
Ki source measurement: = 1.27 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Assay activity
2393950CA2 · ChEMBL activity 2393950
Ki source measurement: = 2.61 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Experimental structure
12CACA2 · PDB 12CA
X-ray diffraction structure mapped through PDBe/SIFTS.
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1A42CA2 · PDB 1A42
X-ray diffraction structure mapped through PDBe/SIFTS.
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1BCDCA2 · PDB 1BCD
X-ray diffraction structure mapped through PDBe/SIFTS.
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1BICCA2 · PDB 1BIC
X-ray diffraction structure mapped through PDBe/SIFTS.
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1BNMCA2 · PDB 1BNM
X-ray diffraction structure mapped through PDBe/SIFTS.
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1KWQCA2 · PDB 1KWQ
X-ray diffraction structure mapped through PDBe/SIFTS.
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1LUGCA2 · PDB 1LUG
X-ray diffraction structure mapped through PDBe/SIFTS.
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1MOOCA2 · PDB 1MOO
X-ray diffraction structure mapped through PDBe/SIFTS.
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3KKXCA2 · PDB 3KKX
Neutron Diffraction structure mapped through PDBe/SIFTS.
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3TMJCA2 · PDB 3TMJ
X-ray diffraction, Neutron Diffraction structure mapped through PDBe/SIFTS.
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4G0CCA2 · PDB 4G0C
Neutron Diffraction structure mapped through PDBe/SIFTS.
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4Q49CA2 · PDB 4Q49
Neutron Diffraction structure mapped through PDBe/SIFTS.
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5C8ICA2 · PDB 5C8I
Neutron Diffraction, X-ray diffraction structure mapped through PDBe/SIFTS.
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6BBSCA2 · PDB 6BBS
Neutron Diffraction, X-ray diffraction structure mapped through PDBe/SIFTS.
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6BC9CA2 · PDB 6BC9
Neutron Diffraction, X-ray diffraction structure mapped through PDBe/SIFTS.
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6GCYCA2 · PDB 6GCY
Neutron Diffraction, X-ray diffraction structure mapped through PDBe/SIFTS.
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6HD2CA2 · PDB 6HD2
Solution NMR structure mapped through PDBe/SIFTS.
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6QEBCA2 · PDB 6QEB
Solid-state NMR structure mapped through PDBe/SIFTS.
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6YMACA2 · PDB 6YMA
Electron crystallography structure mapped through PDBe/SIFTS.
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6YMBCA2 · PDB 6YMB
Electron crystallography structure mapped through PDBe/SIFTS.
Inspect full recordReaction assignment
RHEA:10748CA2 · RHEA:10748 assignment
Protein-specific UniProt catalytic-activity assignment joined to a balanced Rhea master reaction.
Inspect full recordAssay activity
2250659CA3 · ChEMBL activity 2250659
Kinact source measurement: = 2.0 10'5nM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING, UNSUPPORTED_UNIT
Inspect full record Assay activity
2456863CA3 · ChEMBL activity 2456863
Kinact source measurement: = 6.56 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Experimental structure
1Z93CA3 · PDB 1Z93
X-ray diffraction structure mapped through PDBe/SIFTS.
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1Z97CA3 · PDB 1Z97
X-ray diffraction structure mapped through PDBe/SIFTS.
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2HFWCA3 · PDB 2HFW
X-ray diffraction structure mapped through PDBe/SIFTS.
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3UYNCA3 · PDB 3UYN
X-ray diffraction structure mapped through PDBe/SIFTS.
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3UYQCA3 · PDB 3UYQ
X-ray diffraction structure mapped through PDBe/SIFTS.
Inspect full recordReaction assignment
RHEA:10748CA3 · RHEA:10748 assignment
Protein-specific UniProt catalytic-activity assignment joined to a balanced Rhea master reaction.
Inspect full recordAssay activity
2456864CA4 · ChEMBL activity 2456864
Kinact source measurement: = 8.41 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Assay activity
2630964CA4 · ChEMBL activity 2630964
KA source measurement: = 7.3 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Experimental structure
1ZNCCA4 · PDB 1ZNC
X-ray diffraction structure mapped through PDBe/SIFTS.
Inspect full recordExperimental structure
3F7BCA4 · PDB 3F7B
X-ray diffraction structure mapped through PDBe/SIFTS.
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3F7UCA4 · PDB 3F7U
X-ray diffraction structure mapped through PDBe/SIFTS.
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3FW3CA4 · PDB 3FW3
X-ray diffraction structure mapped through PDBe/SIFTS.
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5IPZCA4 · PDB 5IPZ
X-ray diffraction structure mapped through PDBe/SIFTS.
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5JN8CA4 · PDB 5JN8
X-ray diffraction structure mapped through PDBe/SIFTS.
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5JN9CA4 · PDB 5JN9
X-ray diffraction structure mapped through PDBe/SIFTS.
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5JNACA4 · PDB 5JNA
X-ray diffraction structure mapped through PDBe/SIFTS.
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5JNCCA4 · PDB 5JNC
X-ray diffraction structure mapped through PDBe/SIFTS.
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5KU6CA4 · PDB 5KU6
X-ray diffraction structure mapped through PDBe/SIFTS.
Inspect full recordReaction assignment
RHEA:10748CA4 · RHEA:10748 assignment
Protein-specific UniProt catalytic-activity assignment joined to a balanced Rhea master reaction.
Inspect full recordAssay activity
2456865CA5A · ChEMBL activity 2456865
Kinact source measurement: = 7.06 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Assay activity
2491977CA5A · ChEMBL activity 2491977
Ki source measurement: = 917.0 nM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Reaction assignment
RHEA:10748CA5A · RHEA:10748 assignment
Protein-specific UniProt catalytic-activity assignment joined to a balanced Rhea master reaction.
Inspect full recordAssay activity
2456866CA5B · ChEMBL activity 2456866
Kinact source measurement: = 9.04 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Assay activity
2491984CA5B · ChEMBL activity 2491984
Ki source measurement: = 9.0 nM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Reaction assignment
RHEA:10748CA5B · RHEA:10748 assignment
Protein-specific UniProt catalytic-activity assignment joined to a balanced Rhea master reaction.
Inspect full recordAssay activity
2456867CA6 · ChEMBL activity 2456867
Kinact source measurement: = 4.93 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Assay activity
2491991CA6 · ChEMBL activity 2491991
Ki source measurement: = 1347.0 nM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Experimental structure
3FE4CA6 · PDB 3FE4
X-ray diffraction structure mapped through PDBe/SIFTS.
Inspect full recordReaction assignment
RHEA:10748CA6 · RHEA:10748 assignment
Protein-specific UniProt catalytic-activity assignment joined to a balanced Rhea master reaction.
Inspect full recordAssay activity
2456868CA7 · ChEMBL activity 2456868
Kinact source measurement: = 5.73 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Assay activity
2619680CA7 · ChEMBL activity 2619680
Ki source measurement: = 5.1 nM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Experimental structure
3MDZCA7 · PDB 3MDZ
X-ray diffraction structure mapped through PDBe/SIFTS.
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3ML5CA7 · PDB 3ML5
X-ray diffraction structure mapped through PDBe/SIFTS.
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6G4TCA7 · PDB 6G4T
X-ray diffraction structure mapped through PDBe/SIFTS.
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6H36CA7 · PDB 6H36
X-ray diffraction structure mapped through PDBe/SIFTS.
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6H37CA7 · PDB 6H37
X-ray diffraction structure mapped through PDBe/SIFTS.
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6H38CA7 · PDB 6H38
X-ray diffraction structure mapped through PDBe/SIFTS.
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6ZR9CA7 · PDB 6ZR9
X-ray diffraction structure mapped through PDBe/SIFTS.
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8Q3UCA7 · PDB 8Q3U
X-ray diffraction structure mapped through PDBe/SIFTS.
Inspect full recordReaction assignment
RHEA:10748CA7 · RHEA:10748 assignment
Protein-specific UniProt catalytic-activity assignment joined to a balanced Rhea master reaction.
Inspect full recordExperimental structure
2W2JCA8 · PDB 2W2J
X-ray diffraction structure mapped through PDBe/SIFTS.
Inspect full recordAssay activity
2393967CA9 · ChEMBL activity 2393967
Ki source measurement: = 1.84 uM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Assay activity
2598328CA9 · ChEMBL activity 2598328
Ki source measurement: = 26.0 nM. No cross-assay comparison is prequalified.
Comparison refused · CONDITION_MISSING
Inspect full record Experimental structure
2HKFCA9 · PDB 2HKF
X-ray diffraction structure mapped through PDBe/SIFTS.
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3IAICA9 · PDB 3IAI
X-ray diffraction structure mapped through PDBe/SIFTS.
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5DVXCA9 · PDB 5DVX
X-ray diffraction structure mapped through PDBe/SIFTS.
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5FL4CA9 · PDB 5FL4
X-ray diffraction structure mapped through PDBe/SIFTS.
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5FL6CA9 · PDB 5FL6
X-ray diffraction structure mapped through PDBe/SIFTS.
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6RQQCA9 · PDB 6RQQ
X-ray diffraction structure mapped through PDBe/SIFTS.
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6RQUCA9 · PDB 6RQU
X-ray diffraction structure mapped through PDBe/SIFTS.
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8Q19CA9 · PDB 8Q19
X-ray diffraction structure mapped through PDBe/SIFTS.
Inspect full recordReaction assignment
RHEA:10748CA9 · RHEA:10748 assignment
Protein-specific UniProt catalytic-activity assignment joined to a balanced Rhea master reaction.
Inspect full record