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Human metabolism / connected atlas human-metabolism-r97-map-v2

Human metabolism — an explorable reaction field

Follow carbon, nitrogen, electrons, and activated groups through a source-linked human metabolic field. Begin with the whole system, then focus until every reaction becomes readable chemistry.

Release sources
Reactome
97
Rhea
141
UniProtKB
2026_02
Accessed
2026-07-14
Filters
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Entity types
Interactive human metabolism atlas A connected overview of central carbon, mitochondrial energy, lipids, amino nitrogen, nucleotides, cofactors, and biological oxidations. Search or select a focus map to inspect pathway and reaction detail. Use List view for a non-spatial alternative.
Building the connected field

Loading authored routes and source-linked stations.

Whole metabolism
FIELD— objectsReactome · Rhea · ChEBI
Orientation
Carbon / material flow Electron / energy transfer Membrane transport Contextual relation ● Metabolite hub ◆ Reaction junction
Read the field

What the overview is showing you

Open / close
01

Shared carbon hubs

Pyruvate, acetyl-CoA, oxaloacetate, 2-oxoglutarate, and related stations connect routes without pretending every shared carrier is a meaningful shortcut.

02

Compartment is identity

The same molecule in cytosol and mitochondrial matrix appears as two pools joined only by a sourced transport event.

03

Zoom reveals chemistry

The whole field stays spare. Focus maps reveal pathway rails; pathway and reaction focus reveal source-backed structures, enzymes, cofactors, and evidence.

04

Topology, not flux

Lines show represented chemical connectivity and direction, not tissue abundance, rate, thermodynamic commitment, or physiological flux.

Mechanistic inset / flagship identity

Oxalosuccinate belongs inside the IDH story—not as a generic pool.

The atlas keeps NAD-dependent and NADP-dependent isocitrate dehydrogenase contexts distinct. At reaction focus, (S)-oxalosuccinate appears between oxidation and decarboxylation with its own structure, charge, stable ChEBI identity, and component Rhea records.

CHEBI:153066RHEA:25589RHEA:19382
Source-backed two-dimensional structure of (S)-oxalosuccinate
(S)-oxalosuccinate · ChEBI release 253 depiction
Release boundary and source model

The map shows curated reaction direction and compartment identity, not measured flux, concentration, tissue dominance or thermodynamic magnitude. Animated traversal marks a selected route only.

This visual projection is an authored learning layer over release-pinned Reactome events, Rhea net reactions, ChEBI identities, and cited literature. Every contextual connection is marked separately from event-backed chemistry.

Read the methodologyInspect source releases