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CA11 · ChEMBL activity 1980545

Kinact source measurement: = 5.7 nM. No cross-assay comparison is prequalified.

Assay activity1980545Admitted release record

Source assertion

ChEMBL direct single-protein activity record with source-reported and source-standardized lexical values preserved.
Evidence ID
ACTIVITY:ChEMBL_37:1980545
Subject dossier
ca11
Source chain
uniprot + chembl
Upstream record
1980545
Corpus snapshot
2026-07-14T09:23:31Z
Admission status
Admitted release record

Lossless activity measurement

Source-reported value
= 5.7 nM
Source-standardized value
= 5.7 nM
Reported endpoint
Kinact
Standardized endpoint
Kinact
Reported upper bound
not reported in admitted source fields
Reported text value
not reported in admitted source fields
Standardization flag
0
pChEMBL from source
not reported in admitted source fields

Reported and source-standardized fields are displayed separately and retain their exact lexical values. The standardized field does not overwrite the upstream report.

Record-local comparison refusalCATALYTIC_STATUS_MISMATCH · CONDITION_MISSING

No cross-assay comparison is authorized by this record. Evaluate target, construct, endpoint, relation, units, assay format, conditions, and exact molecular form first.

Catalytic-status interpretation boundary

The protein dossier is classified as acatalytic related. This ChEMBL activity remains admitted as a source-reported experimental record, but it does not reclassify the protein as catalytic or authorize ranking it against catalytic paralogs.

Assay and target

ChEMBL activity
1980545
Target
CHEMBL2420 · SINGLE PROTEIN
Assay
CHEMBL897979 · Binding (B)
BAO format
BAO_0000357 · single protein format
BAO endpoint
BAO_0000179
Target confidence
9 · Direct single protein target assigned
Source quality flags
potential_duplicate=0 · data_validity_comment=not reported in admitted source fields
Upstream assay description

Inhibition of cloned catalytic domani of human carbonic anhydrase 11 by CO2 hydration stopped-flow assay

Compound identity

Molecule
CHEMBL20 · ACETAZOLAMIDE
Parent form
CHEMBL20 · is_parent_form=true
Molecule type
Small molecule
Chirality source code
2
Standard InChIKey
BZKPWHYZMXOIDC-UHFFFAOYSA-N
Canonical SMILES
CC(=O)Nc1nnc(S(N)(=O)=O)s1
Standard InChI
InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)

Document

Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.

Colinas PA, Bravo RD, Vullo D, Scozzafava A, Supuran CT.

ChEMBL document
CHEMBL1149682
Journal / year
Bioorg Med Chem Lett · 2007
PubMed
17658252

Comparison state

Prequalified
No — pairwise evaluation is still required
Protein identity
O75493 · taxon 9606
Variant / construct
not reported in admitted source fields / not reported in admitted source fields
Conditions
pH not reported in admitted source fields · temperature not reported in admitted source fields °C · substrate not reported in admitted source fields · buffer not reported in admitted source fields

Snapshot provenance

Each retained corpus build input is identified by retrieval time, snapshot path, SHA-256 digest, and exact upstream request. The snapshot files are not embedded in the served binary; the provenance identifiers remain dependencies of this one admitted record, not interchangeable citations.

RetrievedSnapshotSHA-256Upstream request
2026-07-14T09:21:33Zraw/uniprot/entries/O75493.json1c27d284e17a666e94656536119b00789c29f98abb86ee46caf2abcdba8a01c0Open exact source
2026-07-14T09:22:20Zraw/chembl/targets/CHEMBL2420.json3b55a351a51ea152bc923f22a2c49d02ffbd89b2057015c5cdb57de2c826ba59Open exact source
2026-07-14T09:22:42Zraw/chembl/direct-assays/CHEMBL2420.jsona214f4d8db9b267940d0b2ce7bad920c51e2193c0bd5c90ce20eed5015514428Open exact source
2026-07-14T09:23:08Zraw/chembl/assay-activities/CHEMBL897979.json1ee7404bf0524b827df0b5af537c316c17ec0880688d28114111c7afe7fa3f4fOpen exact source
2026-07-14T09:23:28Zraw/chembl/activities/1980545.jsonf272febeb41355ff59a5b338fcdf4082acb5820c2a8f7eb491cc3de1538dbb06Open exact source
2026-07-14T09:23:27Zraw/chembl/assays/CHEMBL897979.json32955cfc0b54529d37f16b61b9f6d82d48c41b055aeccb724ec8992c929e55e0Open exact source
2026-07-14T09:23:20Zraw/chembl/molecules/CHEMBL20.json6b07a8754aad1e0e3a2ad71a185215a21d0c942143f77e80555dd6d7fe39df19Open exact source
2026-07-14T09:23:28Zraw/chembl/documents/CHEMBL1149682.jsond46206b0244bc757f6eced38e6c63296bf64b20e3d8ab9e1babb747bfb6170ddOpen exact source