Source assertion
ChEMBL direct single-protein activity record with source-reported and source-standardized lexical values preserved.
Lossless activity measurement
- Source-reported value
- = 4.49 uM
- Source-standardized value
- = 4490.0 nM
- Reported endpoint
- IC50
- Standardized endpoint
- IC50
- Reported upper bound
- not reported in admitted source fields
- Reported text value
- not reported in admitted source fields
- Standardization flag
- 1
- pChEMBL from source
- 5.35
Reported and source-standardized fields are displayed separately and retain their exact lexical values. The standardized field does not overwrite the upstream report.
Record-local comparison refusalCONDITION_MISSING
No cross-assay comparison is authorized by this record. Evaluate target, construct, endpoint, relation, units, assay format, conditions, and exact molecular form first.
Assay and target
- ChEMBL activity
2259038- Target
CHEMBL205· SINGLE PROTEIN- Assay
CHEMBL1002070· Binding (B)- BAO format
BAO_0000357· single protein format- BAO endpoint
BAO_0000190- Target confidence
- 9 · Direct single protein target assigned
- Source quality flags
- potential_duplicate=0 · data_validity_comment=not reported in admitted source fields
Upstream assay description
Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry
Compound identity
- Molecule
CHEMBL421· SULFASALAZINE- Parent form
CHEMBL421· is_parent_form=true- Molecule type
- Small molecule
- Chirality source code
- 2
- Standard InChIKey
NCEXYHBECQHGNR-QZQOTICOSA-N- Canonical SMILES
O=C(O)c1cc(/N=N/c2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O- Standard InChI
InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
Document
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
Bayram E, Senturk M, Kufrevioglu OI, Supuran CT.
- ChEMBL document
CHEMBL1152236- Journal / year
- Bioorg Med Chem · 2008
- PubMed
- 18819808
Comparison state
- Prequalified
- No — pairwise evaluation is still required
- Protein identity
- P00918 · taxon 9606
- Variant / construct
- not reported in admitted source fields / not reported in admitted source fields
- Conditions
- pH not reported in admitted source fields · temperature not reported in admitted source fields °C · substrate not reported in admitted source fields · buffer not reported in admitted source fields
Snapshot provenance
Each retained corpus build input is identified by retrieval time, snapshot path, SHA-256 digest, and exact upstream request. The snapshot files are not embedded in the served binary; the provenance identifiers remain dependencies of this one admitted record, not interchangeable citations.
| Retrieved | Snapshot | SHA-256 | Upstream request |
|---|---|---|---|
| 2026-07-14T09:21:31Z | raw/uniprot/entries/P00918.json | ed44906dd1b976f4c8b0399e9e3a7a4af09b673c035a201e218a4880821c1179 | Open exact source |
| 2026-07-14T09:22:21Z | raw/chembl/targets/CHEMBL205.json | a72211a98500a9ee255af420c327df455642440f828570896f227f637ac4d991 | Open exact source |
| 2026-07-14T09:22:24Z | raw/chembl/direct-assays/CHEMBL205.json | d77687649ad2c1120e6590de641bdef7dd078d9d00a04b12d1196c7031cceb65 | Open exact source |
| 2026-07-14T09:22:50Z | raw/chembl/assay-activities/CHEMBL1002070.json | e0515a689c6080748e8a1581e51964c60c4dc3ef1b32367b177ba1c81b0e1d18 | Open exact source |
| 2026-07-14T09:23:16Z | raw/chembl/activities/2259038.json | d4b07107969fade35093a09ccc5696167721fc7a26478db3147d567e5cd9f0b9 | Open exact source |
| 2026-07-14T09:23:17Z | raw/chembl/assays/CHEMBL1002070.json | 0275bdb5765abe94ca5838cb8100c9529100dcaa348784141d65bcd5f3099534 | Open exact source |
| 2026-07-14T09:23:16Z | raw/chembl/molecules/CHEMBL421.json | 1c3533138be7d06cb55fcdea1c59b78dd6cd8fdf33720bf5fd4f109380cba3e4 | Open exact source |
| 2026-07-14T09:23:15Z | raw/chembl/documents/CHEMBL1152236.json | fb726436f5f7c23d80784a02dc4a3b2bdd6e1e37f48047bb8a0155fbc4250001 | Open exact source |