Source assertion

ChEMBL direct single-protein activity record with source-reported and source-standardized lexical values preserved.

Evidence ID: ACTIVITY:ChEMBL_37:2259064
Subject dossier: ca2
Source chain: uniprot + chembl
Upstream record: 2259064
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: Admitted release record

Lossless activity measurement

Source-reported value: = 1.27 uM
Source-standardized value: = 1270.0 nM
Reported endpoint: Ki
Standardized endpoint: Ki
Reported upper bound: not reported in admitted source fields
Reported text value: not reported in admitted source fields
Standardization flag: 1
pChEMBL from source: 5.90

Reported and source-standardized fields are displayed separately and retain their exact lexical values. The standardized field does not overwrite the upstream report.

Record-local comparison refusalCONDITION_MISSING

No cross-assay comparison is authorized by this record. Evaluate target, construct, endpoint, relation, units, assay format, conditions, and exact molecular form first.

Assay and target

ChEMBL activity: 2259064
Target: CHEMBL205 · SINGLE PROTEIN
Assay: CHEMBL1002075 · Binding (B)
BAO format: BAO_0000357 · single protein format
BAO endpoint: BAO_0000192
Target confidence: 9 · Direct single protein target assigned
Source quality flags: potential_duplicate=0 · data_validity_comment=not reported in admitted source fields

Upstream assay description

Inhibition of human carbonic anhydrase 2 esterase activity by uncompetitive Lineweaver-Burke plot

Compound identity

Molecule: CHEMBL1375 · 5-CHLOROSALICYLIC ACID
Parent form: CHEMBL1375 · is_parent_form=true
Molecule type: Small molecule
Chirality source code: -1
Standard InChIKey: NKBASRXWGAGQDP-UHFFFAOYSA-N
Canonical SMILES: O=C(O)c1cc(Cl)ccc1O
Standard InChI: InChI=1S/C7H5ClO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,(H,10,11)

Document

In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.

Bayram E, Senturk M, Kufrevioglu OI, Supuran CT.

ChEMBL document: CHEMBL1152236
Journal / year: Bioorg Med Chem · 2008
DOI: 10.1016/j.bmc.2008.09.028
PubMed: 18819808

Comparison state

Prequalified: No — pairwise evaluation is still required
Protein identity: P00918 · taxon 9606
Variant / construct: not reported in admitted source fields / not reported in admitted source fields
Conditions: pH not reported in admitted source fields · temperature not reported in admitted source fields °C · substrate not reported in admitted source fields · buffer not reported in admitted source fields

Snapshot provenance

Each retained corpus build input is identified by retrieval time, snapshot path, SHA-256 digest, and exact upstream request. The snapshot files are not embedded in the served binary; the provenance identifiers remain dependencies of this one admitted record, not interchangeable citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:31Z	`raw/uniprot/entries/P00918.json`	`ed44906dd1b976f4c8b0399e9e3a7a4af09b673c035a201e218a4880821c1179`	Open exact source
2026-07-14T09:22:21Z	`raw/chembl/targets/CHEMBL205.json`	`a72211a98500a9ee255af420c327df455642440f828570896f227f637ac4d991`	Open exact source
2026-07-14T09:22:24Z	`raw/chembl/direct-assays/CHEMBL205.json`	`d77687649ad2c1120e6590de641bdef7dd078d9d00a04b12d1196c7031cceb65`	Open exact source
2026-07-14T09:22:50Z	`raw/chembl/assay-activities/CHEMBL1002075.json`	`b31c9e09c5791a8baa6ba2f9bdc648a3088a4f15ab9f9e78254b8d3ac030d41d`	Open exact source
2026-07-14T09:23:18Z	`raw/chembl/activities/2259064.json`	`ddd8b2d02aa71d007b5ba142fce920f52098e720a433c2705e6f09bc9524e949`	Open exact source
2026-07-14T09:23:16Z	`raw/chembl/assays/CHEMBL1002075.json`	`cae69b809ff44c420848f35a7032cc297bbd8b51627a6d7c5cfd10cf0d65389b`	Open exact source
2026-07-14T09:23:16Z	`raw/chembl/molecules/CHEMBL1375.json`	`0530dd35177199b1cd6a0a5296ab07af7fcde7ad7cc296556370268de87a2c44`	Open exact source
2026-07-14T09:23:15Z	`raw/chembl/documents/CHEMBL1152236.json`	`fb726436f5f7c23d80784a02dc4a3b2bdd6e1e37f48047bb8a0155fbc4250001`	Open exact source