Source assertion

ChEMBL direct single-protein activity record with source-reported and source-standardized lexical values preserved.

Evidence ID: ACTIVITY:ChEMBL_37:2456868
Subject dossier: ca7
Source chain: uniprot + chembl
Upstream record: 2456868
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: Admitted release record

Lossless activity measurement

Source-reported value: = 5.73 uM
Source-standardized value: = 5.73 uM
Reported endpoint: Kinact
Standardized endpoint: Kinact
Reported upper bound: not reported in admitted source fields
Reported text value: not reported in admitted source fields
Standardization flag: 0
pChEMBL from source: not reported in admitted source fields

Reported and source-standardized fields are displayed separately and retain their exact lexical values. The standardized field does not overwrite the upstream report.

Record-local comparison refusalCONDITION_MISSING

No cross-assay comparison is authorized by this record. Evaluate target, construct, endpoint, relation, units, assay format, conditions, and exact molecular form first.

Assay and target

ChEMBL activity: 2456868
Target: CHEMBL2326 · SINGLE PROTEIN
Assay: CHEMBL1022728 · Binding (B)
BAO format: BAO_0000357 · single protein format
BAO endpoint: BAO_0000179
Target confidence: 9 · Direct single protein target assigned
Source quality flags: potential_duplicate=0 · data_validity_comment=not reported in admitted source fields

Upstream assay description

Inhibition of human recombinant carbonic anhydrase 7 by stopped flow CO2 hydration method

Compound identity

Molecule: CHEMBL442687 · TIOXOLONE
Parent form: CHEMBL442687 · is_parent_form=true
Molecule type: Small molecule
Chirality source code: 2
Standard InChIKey: SLYPOVJCSQHITR-UHFFFAOYSA-N
Canonical SMILES: O=c1oc2cc(O)ccc2s1
Standard InChI: InChI=1S/C7H4O3S/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3,8H

Document

Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?

Innocenti A, Maresca A, Scozzafava A, Supuran CT.

ChEMBL document: CHEMBL1155067
Journal / year: Bioorg Med Chem Lett · 2008
DOI: 10.1016/j.bmcl.2008.06.024
PubMed: 18572406

Comparison state

Prequalified: No — pairwise evaluation is still required
Protein identity: P43166 · taxon 9606
Variant / construct: not reported in admitted source fields / not reported in admitted source fields
Conditions: pH not reported in admitted source fields · temperature not reported in admitted source fields °C · substrate not reported in admitted source fields · buffer not reported in admitted source fields

Snapshot provenance

Each retained corpus build input is identified by retrieval time, snapshot path, SHA-256 digest, and exact upstream request. The snapshot files are not embedded in the served binary; the provenance identifiers remain dependencies of this one admitted record, not interchangeable citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:32Z	`raw/uniprot/entries/P43166.json`	`dc0ec23dc5d7dfcf4737e905d75df89f664cdb3e05519fcfef79fbaf218da84f`	Open exact source
2026-07-14T09:22:19Z	`raw/chembl/targets/CHEMBL2326.json`	`62691ca1f8537e95ebb7067dc86d7bc8dc2258b418c22d6317910ba5c87d371b`	Open exact source
2026-07-14T09:22:38Z	`raw/chembl/direct-assays/CHEMBL2326.json`	`f0238fb298d0c0e9bc652a3268f81791d92dc1c422ccc9a447278e125104c829`	Open exact source
2026-07-14T09:23:01Z	`raw/chembl/assay-activities/CHEMBL1022728.json`	`77363b0cbb9802f7fcdf45ca1e241e2352ee46426e8d90500cefdda07583b9fe`	Open exact source
2026-07-14T09:23:26Z	`raw/chembl/activities/2456868.json`	`41a505781651b0eaea8989194f3c731ceddf55f0b85b2f74e3f41a775b36d761`	Open exact source
2026-07-14T09:23:26Z	`raw/chembl/assays/CHEMBL1022728.json`	`07d3b2644d8b9cf7ca594b4c490bc1a62f8363392f734f5dcbbb132f0e4e1a17`	Open exact source
2026-07-14T09:23:19Z	`raw/chembl/molecules/CHEMBL442687.json`	`f152b44651db17cb570a3d901bba045a331eebd01e4fac702cecfbf64650aa99`	Open exact source
2026-07-14T09:23:19Z	`raw/chembl/documents/CHEMBL1155067.json`	`a852cdb1b30571a0f6ed5def67b2c61a1b73e56c6483dd07330b61bc3a77e725`	Open exact source