Source assertion

hydrogencarbonate + H(+) = CO2 + H2O

Evidence ID: REACTION:UNIPROT:P22748:RHEA:10748
Subject dossier: ca4
Source chain: uniprot + rhea
Upstream record: RHEA:10748
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: Admitted release record

Protein-specific reaction assignment

hydrogencarbonate + H(+) = CO2 + H2O

Rhea master reaction: RHEA:10748
EC number: 4.2.1.1
Enzyme class: EC:4.2.1.1 carbonic anhydrase
UniProt reaction name: hydrogencarbonate + H(+) = CO2 + H2O

Assignment evidence

Evidence code	Source	Identifier
`ECO:0000269`	PubMed	15563508
`ECO:0000269`	PubMed	16686544
`ECO:0000269`	PubMed	16807956
`ECO:0000269`	PubMed	17127057
`ECO:0000269`	PubMed	17314045
`ECO:0000269`	PubMed	17652713
`ECO:0000269`	PubMed	17705204
`ECO:0000269`	PubMed	18618712
`ECO:0000269`	PubMed	19186056
`ECO:0000269`	PubMed	19206230
`ECO:0000269`	PubMed	7625839

Cross-references

Interpretation boundary

No directional flux is claimed. No kinetic parameter is claimed. No tissue activity is claimed. The record supports the protein-to-reaction assignment and balanced reaction identity only.

Snapshot provenance

Each retained corpus build input is identified by retrieval time, snapshot path, SHA-256 digest, and exact upstream request. The snapshot files are not embedded in the served binary; the provenance identifiers remain dependencies of this one admitted record, not interchangeable citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:32Z	`raw/uniprot/entries/P22748.json`	`28fa76c5a216b9356479d42199f709dd46e662172f2872078a5491cfe2c618f1`	Open exact source
2026-07-14T09:21:29Z	`raw/rhea/reaction-10748.tsv`	`7144817ba5674817b1ae7fdb610382232253c7dae26443fbc1a63a4761cab80c`	Open exact source
2026-07-14T09:21:29Z	`raw/rhea/rhea-release.properties`	`83f707a0293fa5b3c3f860836b5b60bcdb64bd0a3921f4ebebf63f4a0a7439b7`	Open exact source