Source assertion

PDBe/SIFTS maps PDB 2HFW to UniProt P07451 with chain-level identity and coverage retained.

Evidence ID: STRUCTURE:PDB:2HFW:UNIPROT:P07451
Subject dossier: ca3
Source chain: uniprot + pdbe
Upstream record: 2HFW
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: Admitted release record

Experimental structure

Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III

PDB ID: 2HFW
Experimental method: X-ray diffraction
Resolution: %!f(*float64=0xc001ffeb90) Å
SIFTS identifier: CAH3_HUMAN
Deposited: 20060626
Released / revised: 20070508 / 20240214

Chain-level mapping

Entity	Chain	Structural asym	Identity	Coverage	UniProt range
1	`A`	`A`	98.0%	100.0%	1–260

Experimental constructs

Entity	Chains / asym IDs	Molecule	Length	Mutation flag	Preparation
1	A / A	Carbonic anhydrase 3polypeptide(L)	260 residues	K64H, R67N, C182S, C187S	Genetically manipulated

Interpretation boundary

This record represents an experimentally determined structure, not a predicted model. A co-crystal ligand, if present upstream, does not by itself establish affinity. This record does not infer kinetics, pathway rate, or metabolic flux.

Snapshot provenance

Each retained corpus build input is identified by retrieval time, snapshot path, SHA-256 digest, and exact upstream request. The snapshot files are not embedded in the served binary; the provenance identifiers remain dependencies of this one admitted record, not interchangeable citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:32Z	`raw/uniprot/entries/P07451.json`	`cf4d0cf96a6252efc608b8ee5c8b35b502dffa8996e6dbb74c6fa4b67ce3394f`	Open exact source
2026-07-14T09:21:49Z	`raw/pdbe/mappings/2hfw.json`	`e1db3c5e6386fe4ccec4387812dc828f4e05304f9928b5e329a34e391c83aa89`	Open exact source
2026-07-14T09:22:12Z	`raw/pdbe/summary/chunk-01.json`	`dc1743d788d7927148f1208eac8f948637869ee61880999e81df1b79b57a0758`	Open exact source
2026-07-14T09:22:13Z	`raw/pdbe/experiment/chunk-01.json`	`fb047b9406db82cfc2256bd41ead50e4cd5ebf2ca5567e9be661676830294ed8`	Open exact source
2026-07-14T09:22:13Z	`raw/pdbe/molecules/chunk-01.json`	`4eb4d03de4d05f3f3a47f20fd76567c3ee5d6835db325358bbfe62bf45501b2a`	Open exact source