Source assertion

PDBe/SIFTS maps PDB 3ML5 to UniProt P43166 with chain-level identity and coverage retained.

Evidence ID: STRUCTURE:PDB:3ML5:UNIPROT:P43166
Subject dossier: ca7
Source chain: uniprot + pdbe
Upstream record: 3ML5
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: Admitted release record

Experimental structure

Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide

PDB ID: 3ML5
Experimental method: X-ray diffraction
Resolution: %!f(*float64=0xc000068430) Å
SIFTS identifier: CAH7_HUMAN
Deposited: 20100416
Released / revised: 20110302 / 20241009

Chain-level mapping

Entity	Chain	Structural asym	Identity	Coverage	UniProt range
1	`A`	`A`	99.0%	100.0%	1–264

Experimental constructs

Entity	Chains / asym IDs	Molecule	Length	Mutation flag	Preparation
1	A / A	Carbonic anhydrase 7polypeptide(L)	269 residues	C183S, C217S	Genetically manipulated

Interpretation boundary

This record represents an experimentally determined structure, not a predicted model. A co-crystal ligand, if present upstream, does not by itself establish affinity. This record does not infer kinetics, pathway rate, or metabolic flux.

Snapshot provenance

Each retained corpus build input is identified by retrieval time, snapshot path, SHA-256 digest, and exact upstream request. The snapshot files are not embedded in the served binary; the provenance identifiers remain dependencies of this one admitted record, not interchangeable citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:32Z	`raw/uniprot/entries/P43166.json`	`dc0ec23dc5d7dfcf4737e905d75df89f664cdb3e05519fcfef79fbaf218da84f`	Open exact source
2026-07-14T09:21:58Z	`raw/pdbe/mappings/3ml5.json`	`2ef3a24a608d2bc54c1ff780b6f4903b4582cfaaad18f6c2fe3ad10fa2b32ca6`	Open exact source
2026-07-14T09:22:14Z	`raw/pdbe/summary/chunk-02.json`	`79ac3fb4e9e30c8c858b4d8ed8bbe6f85e8e0d0e3630627a999691f40a3d330d`	Open exact source
2026-07-14T09:22:14Z	`raw/pdbe/experiment/chunk-02.json`	`e42f681713cd9cdce851cc48738b3c6e0f0c075d0006a640c484bcab84561898`	Open exact source
2026-07-14T09:22:15Z	`raw/pdbe/molecules/chunk-02.json`	`27833f4d4cb9a9bfcb110f6e551fe2a5ccef01ccea4dda947132af6c51bd66e6`	Open exact source