Source assertion

PDBe/SIFTS maps PDB 4HT2 to UniProt O43570 with chain-level identity and coverage retained.

Evidence ID: STRUCTURE:PDB:4HT2:UNIPROT:O43570
Subject dossier: ca12
Source chain: uniprot + pdbe
Upstream record: 4HT2
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: Admitted release record

Experimental structure

Crystal structure of human carbonic anhydrase isozyme XII with the inhibitor.

PDB ID: 4HT2
Experimental method: X-ray diffraction
Resolution: %!f(*float64=0xc000068850) Å
SIFTS identifier: CAH12_HUMAN
Deposited: 20121031
Released / revised: 20130410 / 20241127

Chain-level mapping

Entity	Chain	Structural asym	Identity	Coverage	UniProt range
1	`A`	`A`	100.0%	79.4%	30–291
1	`B`	`B`	100.0%	79.4%	30–291
1	`C`	`C`	100.0%	79.4%	30–291
1	`D`	`D`	100.0%	79.4%	30–291

Experimental constructs

Entity	Chains / asym IDs	Molecule	Length	Mutation flag	Preparation
1	A, B, C, D / A, B, C, D	Carbonic anhydrase 12polypeptide(L)	263 residues	not reported in admitted source fields	Genetically manipulated

Interpretation boundary

This record represents an experimentally determined structure, not a predicted model. A co-crystal ligand, if present upstream, does not by itself establish affinity. This record does not infer kinetics, pathway rate, or metabolic flux.

Snapshot provenance

Each retained corpus build input is identified by retrieval time, snapshot path, SHA-256 digest, and exact upstream request. The snapshot files are not embedded in the served binary; the provenance identifiers remain dependencies of this one admitted record, not interchangeable citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:33Z	`raw/uniprot/entries/O43570.json`	`5e3bf6d20c857bc7f533ebfbfaf42d7ad6e84050aeb13c8f959567b94eb24d19`	Open exact source
2026-07-14T09:22:06Z	`raw/pdbe/mappings/4ht2.json`	`73e822c2188b9393118935224c5d1d0c90c09159a1289e6aab9f3abe35e72292`	Open exact source
2026-07-14T09:22:14Z	`raw/pdbe/summary/chunk-02.json`	`79ac3fb4e9e30c8c858b4d8ed8bbe6f85e8e0d0e3630627a999691f40a3d330d`	Open exact source
2026-07-14T09:22:14Z	`raw/pdbe/experiment/chunk-02.json`	`e42f681713cd9cdce851cc48738b3c6e0f0c075d0006a640c484bcab84561898`	Open exact source
2026-07-14T09:22:15Z	`raw/pdbe/molecules/chunk-02.json`	`27833f4d4cb9a9bfcb110f6e551fe2a5ccef01ccea4dda947132af6c51bd66e6`	Open exact source