UniProt-reviewed mitochondrial alpha-carbonic-anhydrase scope record. The pathway map shows its reaction context without making tissue, rate or flux claims. This release admits 3 source-linked records for this accession; selection counts are not complete upstream-database counts.
Normalized identity
- Gene
- CA5A
- UniProt accession
P35218- Catalytic status
- Catalytic
- Review state
- UniProt-reviewed
- Taxon
- 9606
- Entry version
- 197 · 2026-06-10
- Sequence identity
- v1 · CRC64
C4E998D269AB1FE5 - Sequence length
- 305 residues
- Selected structures
- 0
- Selected activities
- 2
- Reaction assignments
- 1
- ChEMBL targets
- CHEMBL4789
UniProt identity snapshot provenance
Snapshot paths identify retained corpus build inputs; those source files are not embedded in the served binary. The release keeps the path, digest, retrieval time, and exact upstream request together.
| Retrieved | Build-input snapshot | SHA-256 | Upstream request |
|---|---|---|---|
| 2026-07-14T09:21:32Z | raw/uniprot/entries/P35218.json | 3daaace95b24bb2a3505bfc3dc00d69a45a868bef35d44db5ad2f62660d4ce94 | Open exact source |
Source-reported location comments
- Mitochondrion
UniProt function text
Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3 (PubMed:24530203, PubMed:8356065). Mitochondria are impermeable to HCO3, and thus this intramitochondrial carbonic anhydrase is pivotal in providing HCO3 for multiple mitochondrial enzymes that catalyze the formation of essential metabolites of intermediary metabolism in the urea and Krebs cycles (PubMed:24530203)