Source assertion

ChEMBL direct single-protein activity record with source-reported and source-standardized lexical values preserved.

Evidence ID: ACTIVITY:ChEMBL_37:2456865
Subject dossier: ca5a
Source chain: uniprot + chembl
Upstream record: 2456865
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: Admitted release record

Lossless activity measurement

Source-reported value: = 7.06 uM
Source-standardized value: = 7.06 uM
Reported endpoint: Kinact
Standardized endpoint: Kinact
Reported upper bound: not reported in admitted source fields
Reported text value: not reported in admitted source fields
Standardization flag: 0
pChEMBL from source: not reported in admitted source fields

Reported and source-standardized fields are displayed separately and retain their exact lexical values. The standardized field does not overwrite the upstream report.

Record-local comparison refusalCONDITION_MISSING

No cross-assay comparison is authorized by this record. Evaluate target, construct, endpoint, relation, units, assay format, conditions, and exact molecular form first.

Assay and target

ChEMBL activity: 2456865
Target: CHEMBL4789 · SINGLE PROTEIN
Assay: CHEMBL1022726 · Binding (B)
BAO format: BAO_0000357 · single protein format
BAO endpoint: BAO_0000179
Target confidence: 9 · Direct single protein target assigned
Source quality flags: potential_duplicate=0 · data_validity_comment=not reported in admitted source fields

Upstream assay description

Inhibition of human recombinant carbonic anhydrase 5A by stopped flow CO2 hydration method

Compound identity

Molecule: CHEMBL442687 · TIOXOLONE
Parent form: CHEMBL442687 · is_parent_form=true
Molecule type: Small molecule
Chirality source code: 2
Standard InChIKey: SLYPOVJCSQHITR-UHFFFAOYSA-N
Canonical SMILES: O=c1oc2cc(O)ccc2s1
Standard InChI: InChI=1S/C7H4O3S/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3,8H

Document

Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?

Innocenti A, Maresca A, Scozzafava A, Supuran CT.

ChEMBL document: CHEMBL1155067
Journal / year: Bioorg Med Chem Lett · 2008
DOI: 10.1016/j.bmcl.2008.06.024
PubMed: 18572406

Comparison state

Prequalified: No — pairwise evaluation is still required
Protein identity: P35218 · taxon 9606
Variant / construct: not reported in admitted source fields / not reported in admitted source fields
Conditions: pH not reported in admitted source fields · temperature not reported in admitted source fields °C · substrate not reported in admitted source fields · buffer not reported in admitted source fields

Snapshot provenance

Each retained corpus build input is identified by retrieval time, snapshot path, SHA-256 digest, and exact upstream request. The snapshot files are not embedded in the served binary; the provenance identifiers remain dependencies of this one admitted record, not interchangeable citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:32Z	`raw/uniprot/entries/P35218.json`	`3daaace95b24bb2a3505bfc3dc00d69a45a868bef35d44db5ad2f62660d4ce94`	Open exact source
2026-07-14T09:22:19Z	`raw/chembl/targets/CHEMBL4789.json`	`86dfea3c0c23596e5f5b5f2e6ee176d76f8e4effc80d8f193dc3a568fff03594`	Open exact source
2026-07-14T09:22:31Z	`raw/chembl/direct-assays/CHEMBL4789.json`	`8d4214e3a1e44388d76657f865206df552757578115a1a05b80789f6bccf1942`	Open exact source
2026-07-14T09:22:54Z	`raw/chembl/assay-activities/CHEMBL1022726.json`	`c412ca7080fbbc73706477bfede39e3511dc0da549d7a1f8d33e94c80d663e75`	Open exact source
2026-07-14T09:23:24Z	`raw/chembl/activities/2456865.json`	`c1d5cdb23533cbb51235ba54d6935f2325795d185fc64a299fffdd77b873f170`	Open exact source
2026-07-14T09:23:24Z	`raw/chembl/assays/CHEMBL1022726.json`	`21fa7fce5cd8a49895580ad654479049dc9831dc9182bbb283b3f3f837c1b87a`	Open exact source
2026-07-14T09:23:19Z	`raw/chembl/molecules/CHEMBL442687.json`	`f152b44651db17cb570a3d901bba045a331eebd01e4fac702cecfbf64650aa99`	Open exact source
2026-07-14T09:23:19Z	`raw/chembl/documents/CHEMBL1155067.json`	`a852cdb1b30571a0f6ed5def67b2c61a1b73e56c6483dd07330b61bc3a77e725`	Open exact source