Source assertion
ChEMBL direct single-protein activity record with source-reported and source-standardized lexical values preserved.
Lossless activity measurement
- Source-reported value
- = 32.0 nM
- Source-standardized value
- = 32.0 nM
- Reported endpoint
- Ki
- Standardized endpoint
- Ki
- Reported upper bound
- not reported in admitted source fields
- Reported text value
- not reported in admitted source fields
- Standardization flag
- 1
- pChEMBL from source
- 7.50
Reported and source-standardized fields are displayed separately and retain their exact lexical values. The standardized field does not overwrite the upstream report.
Record-local comparison refusalCONDITION_MISSING
No cross-assay comparison is authorized by this record. Evaluate target, construct, endpoint, relation, units, assay format, conditions, and exact molecular form first.
Assay and target
- ChEMBL activity
2949458- Target
CHEMBL3912· SINGLE PROTEIN- Assay
CHEMBL1048396· Binding (B)- BAO format
BAO_0000357· single protein format- BAO endpoint
BAO_0000192- Target confidence
- 9 · Direct single protein target assigned
- Source quality flags
- potential_duplicate=0 · data_validity_comment=not reported in admitted source fields
Upstream assay description
Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay
Compound identity
- Molecule
CHEMBL21· SULFANILAMIDE- Parent form
CHEMBL21· is_parent_form=true- Molecule type
- Small molecule
- Chirality source code
- 2
- Standard InChIKey
FDDDEECHVMSUSB-UHFFFAOYSA-N- Canonical SMILES
Nc1ccc(S(N)(=O)=O)cc1- Standard InChI
InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)
Document
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.
Temperini C, Innocenti A, Scozzafava A, Parkkila S, Supuran CT.
- ChEMBL document
CHEMBL1154758- Journal / year
- J Med Chem · 2010
- PubMed
- 20028100
Comparison state
- Prequalified
- No — pairwise evaluation is still required
- Protein identity
- Q8N1Q1 · taxon 9606
- Variant / construct
- not reported in admitted source fields / not reported in admitted source fields
- Conditions
- pH not reported in admitted source fields · temperature not reported in admitted source fields °C · substrate not reported in admitted source fields · buffer not reported in admitted source fields
Snapshot provenance
Each retained corpus build input is identified by retrieval time, snapshot path, SHA-256 digest, and exact upstream request. The snapshot files are not embedded in the served binary; the provenance identifiers remain dependencies of this one admitted record, not interchangeable citations.
| Retrieved | Snapshot | SHA-256 | Upstream request |
|---|---|---|---|
| 2026-07-14T09:21:33Z | raw/uniprot/entries/Q8N1Q1.json | 606f7712a41abd05d3b9d0522bbefd377f44b400f37aba7cab2c788361ea41dd | Open exact source |
| 2026-07-14T09:22:20Z | raw/chembl/targets/CHEMBL3912.json | 25c5e2a15ee4b3b77c80ce3f132ac5e1bb083da98ac008a4a0af7dcac97dc1b5 | Open exact source |
| 2026-07-14T09:22:47Z | raw/chembl/direct-assays/CHEMBL3912.json | 1b69e1b7672728589a0f96e68c5abf7840e50b3d7b09f9d1ef52048e47d6afba | Open exact source |
| 2026-07-14T09:23:09Z | raw/chembl/assay-activities/CHEMBL1048396.json | 37acd5950d0b566313be93b55ee97131f6e46504831d707440aaaae34d8bf259 | Open exact source |
| 2026-07-14T09:23:29Z | raw/chembl/activities/2949458.json | b8c42074b4b2bbe47b42126f5e0d20e07c596c530044d226f5dbddd352c2c779 | Open exact source |
| 2026-07-14T09:23:29Z | raw/chembl/assays/CHEMBL1048396.json | 391d504e1319ef9240f856142a24e3b6a725d4988f2faa0e4d172f939988555a | Open exact source |
| 2026-07-14T09:23:29Z | raw/chembl/molecules/CHEMBL21.json | cae58cda448760e0725e0bed4535e45e4648e5d6b843abc403ba5cab2a07f7b5 | Open exact source |
| 2026-07-14T09:23:29Z | raw/chembl/documents/CHEMBL1154758.json | 327d7f0bb5d41473575b71055fc59ad0063774d8f21a305295f817d0924c9a6c | Open exact source |